diaendoСахарный диабетDiabetes mellitus2072-03512072-0378Endocrinology research centre10.14341/DM13232diaendo-13232Research ArticleОригинальные исследованияOriginal StudiesПостпрандиальная секреция инсулина и пептида YY при приеме эритритола и сахарозыPostprandial secretion of insulin and peptide YY when taking erythritol and sucrosehttps://orcid.org/0000-0001-6170-6603СилинаН. В.SilinaN. V.

Силина Наталья Валерьевна

117036, Москва, ул. Дм. Ульянова, д. 11

Natalia V. Silina - MD

11 Dm. Ulyanova street, 117036

s1linanata@yandex.ruhttps://orcid.org/0000-0001-8077-9381МазуринаН. В.MazurinaN. V.

Мазурина Наталия Валентиновна - д.м.н.

Москва

Natalya V. Mazurina - MD, PhD.

Moscow

natalyamazurina@mail.ruhttps://orcid.org/0000-0002-6220-4397ЕршоваЕ. В.ErshovaE. V.

Ершова Екатерина Владимировна - к.м.н.

Москва

Ekaterina V. Ershova - MD, PhD.

Moscow

Ershova.Ekaterina@endocrincentr.ruhttps://orcid.org/0000-0002-6624-2374КомшиловаК. А.KomshilovaK. A.

Комшилова Ксения Андреевна - к.м.н.

Москва

Kseniya A. Komshilova - MD, PhD.

Moscow

ksusha@rambler.ruhttps://orcid.org/0000-0002-1120-8240НиканкинаЛ. В.NikankinaL. V.

Никанкина Лариса Вячеславовна - к.м.н.

Москва

Larisa V. Nikankina - MD, PhD.

Moscow

larisa.nikankina@yandex.ruhttps://orcid.org/0000-0002-9462-8522Першина-МилютинаА. П.Pershina-MilutinaA. P.

Першина-Милютина Анастасия Павловна

Москва

Anastasiia P. Pershina-Miliutina

Moscow

oa11111998@gmail.comhttps://orcid.org/0000-0003-2373-2231АнтоноваК. В.AntonovaK. V.

Антонова Ксения Валентиновна - д.м.н.; Researcher ID: J-9971-2016; Scopus Author ID: 7004672742.

Москва

Ksenia V. Antonova - MD, PhD.; Researcher ID: J-9971-2016; Scopus Author ID: 7004672742.

Moscow

kseniya.antonova@mail.ruhttps://orcid.org/0000-0002-8520-8702ТрошинаЕ. А.TroshinaE. A.

Трошина Екатерина Анатольевна - д.м.н., профессор, член-корр. РАН.

Москва

Ekaterina A. Troshina - MD, PhD, Professor.

Moscow

troshina@inbox.ruГНЦ РФ ФГБУ «Национальный медицинский исследовательский центр эндокринологии»РоссияEndocrinology Research CentreRussian FederationНаучный центр неврологииРоссияResearch Center of NeurologyRussian Federation202418012025276536542Copyright © Силина Н.В., Мазурина Н.В., Ершова Е.В., Комшилова К.А., Никанкина Л.В., Першина-Милютина А.П., Антонова К.В., Трошина Е.А., 20252025Силина Н.В., Мазурина Н.В., Ершова Е.В., Комшилова К.А., Никанкина Л.В., Першина-Милютина А.П., Антонова К.В., Трошина Е.А.Silina N.V., Mazurina N.V., Ershova E.V., Komshilova K.A., Nikankina L.V., Pershina-Milutina A.P., Antonova K.V., Troshina E.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.dia-endojournals.ru/jour/article/view/13232ЦЕЛЬ

ЦЕЛЬ. Изучить влияние некалорийного сахарозаменителя эритритола и комбинации эритритола и сахарозы на постпрандиальную секрецию инсулина и пептида-YY (PYY).

МАТЕРИАЛЫ И МЕТОДЫ

МАТЕРИАЛЫ И МЕТОДЫ. Проведено сравнительное исследование, направленное на оценку влияния эритритола (эритрита), сахарозы и комбинации эритритола и сахарозы на постпрандиальный уровень глюкозы, иммунореактивного инсулина (ИРИ) и PYY. Участники отбирались из числа здоровых добровольцев, в возрасте от 18 до 35 лет. При соответствии участников критериям отбора проводились дальнейшие этапы исследования. В ходе исследования каждый из участников принимал раствор сахарозы 75 г, эритрита 75 г или смеси сахарозы и эритрита (75 г и 25 г соответственно). Дальнейшее определение глюкозы и инсулина проводилось каждые 30 минут, таким образом, показатели глюкозы, инсулина и PYY определялись исходно и на 30-й, 60-й, 90-й и 120-й минутах.

РЕЗУЛЬТАТЫ

РЕЗУЛЬТАТЫ. Были получены данные, подтверждающие отсутствие влияния эритритола на постпрандиальную секрецию инсулина и глюкозы. В нашей работе мы также продемонстрировали снижение постпрандиальной гликемии при совместном приеме сахарозы и эритритола. Сахароза и эритрит в равной степени стимулировали секрецию PYY.

ЗАКЛЮЧЕНИЕ

ЗАКЛЮЧЕНИЕ. Полученные нами данные показывают, что эритритол может рассматриваться в качестве оптимального заменителя сахара у людей с нарушениями углеводного обмена и ожирением.

AIM

AIM. To study the effect of the non-calorie sweetener erythritol and the combination of erythritol and sucrose on postprandial secretion of insulin and peptide-YY (PYY).

MATERIALS AND METHODS

MATERIALS AND METHODS. A comparative study was conducted to assess the effect of erythritol, sucrose and a combination of erythritol and sucrose on postprandial glucose, IRI and PYY levels. The participants were selected from among healthy volunteers, aged 18 to 35 years. If the participants met the selection criteria, further stages of the study were carried out. During the study, each participant took a solution of sucrose 75 g, erythritol 75 g or a mixture of sucrose and erythritol (75 g and 25 g, respectively). Further determination of glucose and insulin was carried out every 30 minutes, so glucose, insulin and PYY values were determined initially and at the 30th, 60th, 90th and 120th minutes.

RESULTS

RESULTS. Data were obtained confirming the absence of the effect of erythritol on postprandial secretion of insulin and glucose. In our work, we also demonstrated a decrease in postprandial glycemia when taking sucrose and erythritol together. Sucrose and erythritol equally stimulated PYY secretion.

CONCLUSION

CONCLUSION. Our data show that erythritol can be considered as an optimal sugar substitute in people with impaired carbohydrate metabolism and obesity.

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The authors declare that there are no conflicts of interest present.