diaendoСахарный диабетDiabetes mellitus2072-03512072-0378Endocrinology research centre10.14341/DM13080diaendo-13080Research ArticleОбзорыReviewЭтнофармакологические аспекты управления сахарным диабетом: исследование лекарственной флоры Шиваликского хребта Гималаев в УттаракхандеEthnopharmacological Insights into Diabetes Management: Exploring Medicinal Flora of Shivalik range of Himalaya in Uttarakhandhttps://orcid.org/0000-0002-4249-1819KumarS.KumarS.

Уттаракханд

Sachin Kumar - Assistant Professor.

Dehradun, Uttarakhand

srai24304@gmail.comhttps://orcid.org/0000-0002-4625-1089KumarA.KumarA.

Райпур, Чхаттисгарх

Ashok Kumar - Professor.

Raipur, Chhattisgarh

ashokmmcp@rediffmail.comhttps://orcid.org/0000-0002-7101-1124TantrayJ.TantrayJ.

Раджастан

Junaid Tantray - Assistant Professor.

Jaipur, Rajasthan

junaidtantray22@gmail.comShuklaA.ShuklaA.

Уттаракханд

Aman Shukla - PhD Scholar.

Dehradun, Uttarakhand,

amanlesnar12@gmail.comУниверситет График Эра ХиллИндияGraphic Era Hill UniversityIndiaИнститут фармации, Калинга УниверситетИндияInstitute of Pharmacy, Kalinga UniversityIndiaИнститут фармации NIMS, NIMS Университет ЖайпурИндияNIMS Institute of Pharmacy, NIMS University JaipurIndia202420112024275498509Copyright © Kumar S., Kumar A., Tantray J., Shukla A., 20242024Kumar S., Kumar A., Tantray J., Shukla A.Kumar S., Kumar A., Tantray J., Shukla A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.dia-endojournals.ru/jour/article/view/13080

Сахарный диабет (СД) — это хроническое метаболическое расстройство, которое часто приводит к угрожающим жизни заболеваниям и постоянно снижает ожидаемую продолжительность жизни. Он характеризуется гипергликемией, возникающей в результате нарушения секреции инсулина, его действия или того и другого. На протяжении тысячелетий наши предки использовали лекарственные растения для профилактики, лечения или даже излечения СД. В последние два-три десятилетия использование этих травяных растений стремительно возросло благодаря их меньшей токсичности и экономической эффективности по сравнению с синтетическими препаратами. В этом обзоре описано около 30 лекарственных растений, которые являются родными для Индии и традиционно используются жителями Шиваликского хребта Гималаев в Уттаракханде (особенно в Дехрадуне и Харидваре) для лечения СД. Данные о этих растениях были собраны из Science Direct, PubMed, Web of Science, Scopus, MDPI, Google Scholar и других поисковых систем и веб-сайтов. Обзор представлен в систематизированном виде, включая ботаническое название, семью, народные названия, используемые части и фармакологическое применение растений в табличной форме. Имеются различные научные доказательства применения некоторых лекарственных растений, которые также упоминаются вместе с кратким описанием каждого из них. Все растения и травы, рассмотренные в этом обзоре, легко доступны в этих районах Уттаракханда, и местные жители традиционно используют их как овощи, приправы и ароматизаторы, обычно включая в свой рацион. Существуют некоторые ограничения фитотерапии, которые не позволяют ей полностью заменить аллопатическую терапию, такие как низкая биодоступность, медленная скорость абсорбции и медленная скорость растворения. Однако с использованием различных современных лекарственных форм (фитосомы, неосомы, липосомы, наночастицы, нанопузырьки, наноалмазы, наношары и т. д.) и методов доставки (различные инвазивные и неинвазивные методы), можно обойти все проблемы, связанные с потенцией и эффективностью фитохимических веществ.

Diabetes mellitus is a chronic metabolic disorder which is commonly found life-threatening disease and it continuously reducing the life expectancy. It is characterized by hyperglycaemia (raised blood sugar level) resulting from defects in insulin secretion, action, or both. Since thousands of years, medicinal plants are being used by our ancestors for the prevention, treatment or even cure the diabetes mellitus. Utilization of these herbal plants is increasing rapidly last two to three decades due to their lesser toxicity and cost effectiveness property as compared to synthetic drugs. In this review, approximately 30 medicinal plants were described which are native to India and traditionally used by the people living in shivalik range of Himalaya in Uttarakhand (specially Dehradun & Haridwar) for the treatment of diabetes mellitus. The data about these plants was collected from science direct, PubMed, web of science, scopus, mdpi, google scholar and different other search engines and websites. This review was conferred in a systematic way as it includes botanical name, family, vernacular name, parts used and pharmacological uses of plants in a tabulated form. There are various scientific evidences behind the uses of some medicinal plants which have been mentioned along with the summary of individual medicinal plant. In this review, all the plants and herbs are easily available in these regions of Uttarakhand and local people traditionally uses these plants as vegetable, seasoning, flavouring and usually consume as a part of their diet. There are some limitations of phytotherapy which limit it to completely replace the allopathic therapy as less bioavailability, less rate of absorption and slow rate of dissolution. But by using various advanced dosage forms (phytosomes, neosomes, liposomes, nanoparticles, nanobubbles, nano diamonds, nanosphere etc.) and method of delivery (various invasive and non-invasive methods) which can bypass these all problems associated with the potency and efficacy of phytochemicals.

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The authors declare that there are no conflicts of interest present.