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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">diaendo</journal-id><journal-title-group><journal-title xml:lang="ru">Сахарный диабет</journal-title><trans-title-group xml:lang="en"><trans-title>Diabetes mellitus</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-0351</issn><issn pub-type="epub">2072-0378</issn><publisher><publisher-name>Endocrinology research centre</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14341/DM13027</article-id><article-id custom-type="elpub" pub-id-type="custom">diaendo-13048</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Новости</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>News</subject></subj-group></article-categories><title-group><article-title>Экзокринная недостаточность поджелудочной железы при сахарном диабете 1 и 2 типа</article-title><trans-title-group xml:lang="en"><trans-title>Pancreatic exocrine insufficiency in diabetes mellitus</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5057-127X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шестакова</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Shestakova</surname><given-names>M. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шестакова Марина Владимировна, д.м.н., профессор, академик РАН</p><p>Scopus Author ID: 7004195530; eLibrary SPIN: 7584-7015</p><p>Москва</p></bio><bio xml:lang="en"><p>Marina V. Shestakova, MD, PhD, Professor, Academician of the Russian Academy of Sciences</p><p>Scopus Author ID: 7004195530; eLibrary SPIN: 7584-7015</p><p>Moscow</p></bio><email xlink:type="simple">Shestakova.Marina@endocrincentr.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6114-564X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Маев</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Maev</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Маев Игорь Вениаминович, д.м.н., профессор, академик РАН</p><p>Scopus Author ID: 7006155179; ResearcherID: N-9320-2014; eLibrary SPIN: 1994-0933</p><p>Москва</p></bio><bio xml:lang="en"><p>Igor V. Maev, MD, PhD, Academician of the Russian Academy of Sciences</p><p>Scopus Author ID: 7006155179; ResearcherID: N-9320-2014; eLibrary SPIN: 1994-0933</p><p>Moscow</p></bio><email xlink:type="simple">igormaev@rambler.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7936-7619</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Аметов</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Ametov</surname><given-names>A. 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Antsiferov, MD, PhD, Professor</p><p>eLibrary SPIN: 1035-4773</p><p>Moscow</p></bio><email xlink:type="simple">antsiferov@rambler.ru</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2815-3992</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бордин</surname><given-names>Д. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Bordin</surname><given-names>D. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Бордин Дмитрий Станиславович, д.м.н., профессор</p><p>Scopus Author ID: 57559491100; ResearcherID: M-4708-2017; eLibrary SPIN: 6331-6323</p><p>Москва; Тверь</p></bio><bio xml:lang="en"><p>Dmitry S. Bordin, MD, PhD, Professor</p><p>Scopus Author ID: 57559491100; ResearcherID: M-4708-2017; eLibrary SPIN: 6331-6323</p><p>Moscow; Tver</p></bio><email xlink:type="simple">dbordin@mail.ru</email><xref ref-type="aff" rid="aff-5"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6581-4521</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Галстян</surname><given-names>Г. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Galstyan</surname><given-names>G. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Галстян Гагик Радикович, д.м.н., профессор</p><p>Scopus Author ID: 6701438348; eLibrary SPIN: 9815-7509</p><p>Москва</p></bio><bio xml:lang="en"><p>Gagik R. Galstyan, MD, PhD, Professor</p><p>Scopus Author ID: 6701438348; eLibrary SPIN: 9815-7509</p><p>Moscow</p></bio><email xlink:type="simple">galstyangagik964@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0327-4619</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дзгоева</surname><given-names>Ф. Х.</given-names></name><name name-style="western" xml:lang="en"><surname>Dzgoeva</surname><given-names>F. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Дзгоева Фатима Хаджимуратовна, к.м.н.</p><p>eLibrary SPIN: 9315-0722</p><p>117036, Москва, ул. Дм. Ульянова, д. 11</p></bio><bio xml:lang="en"><p>Fatima K. Dzgoeva, MD, PhD</p><p>11 Dm. Ulyanova street, 117036 Moscow</p><p>eLibrary SPIN: 9315-0722</p><p>Moscow</p></bio><email xlink:type="simple">fatima.dzgoeva@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7760-2091</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кучерявый</surname><given-names>Ю. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kucheryavyy</surname><given-names>Y. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кучерявый Юрий Александрович, к.м.н., доцент</p><p>eLibrary SPIN: 4503-8807</p><p>Красногорск</p></bio><bio xml:lang="en"><p>Yury A. Kucheryavyy, MD, PhD, Associate Professor</p><p>eLibrary SPIN: 4503-8807</p><p>Krasnogorsk</p></bio><email xlink:type="simple">proped@mail.ru</email><xref ref-type="aff" rid="aff-6"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1316-5245</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мкртумян</surname><given-names>А. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Mkrtumyan</surname><given-names>A. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мкртумян Ашот Мусаелович, д.м.н., профессор</p><p>Author ID: 513441; eLibrary SPIN: 1980-8700</p><p>Москва</p></bio><bio xml:lang="en"><p>Ashot M. Mkrtumyan, MD, PhD, Professor</p><p>Author ID: 513441; eLibrary SPIN: 1980-8700</p><p>Moscow</p></bio><email xlink:type="simple">vagrashot@mail.ru</email><xref ref-type="aff" rid="aff-7"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5656-2596</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Никонова</surname><given-names>Т. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Nikonova</surname><given-names>T. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Никонова Татьяна Васильевна, д.м.н.</p><p>Scopus Author ID: 55553886600; eLibrary SPIN: 8863-0201</p><p>Москва</p></bio><bio xml:lang="en"><p>Tatiana V. Nikonova, MD, PhD</p><p>Scopus Author ID: 55553886600; eLibrary SPIN: 8863-0201</p><p>Moscow</p></bio><email xlink:type="simple">tatiana_nikonova@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1949-914X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пашкова</surname><given-names>Е. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Pashkova</surname><given-names>E. Y.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Пашкова Евгения Юрьевна, к.м.н.</p><p>Scopus Author ID: 57226576419; e-Library SPIN: 4948-8315</p><p>Москва</p></bio><bio xml:lang="en"><p>Evgeniya Y. Pashkova, MD, PhD</p><p>Scopus Author ID: 57226576419; e-Library SPIN: 4948-8315</p><p>Moscow</p></bio><email xlink:type="simple">parlodel@mail.ru</email><xref ref-type="aff" rid="aff-8"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Национальный исследовательский центр эндокринологии</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Endocrinology Research Centre</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Московский государственный медико-стоматологический университет им. А.И. Евдокимова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>A.I. Yevdokimov Moscow State University of Medicine and Dentistry</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Российская медицинская академия непрерывного профессионального образования</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian Medical Academy of Continuous Professional Education</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>Российская медицинская академия непрерывного профессионального образования; Эндокринологический диспансер</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Endocrinological Dispensary of the Moscow City Health Department</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-5"><aff xml:lang="ru"><institution>Московский государственный медико-стоматологический университет им. А.И. Евдокимова; Московский клинический научно-практический центр им. А.С. Логинова; Тверской государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>A.I. Yevdokimov Moscow State University of Medicine and Dentistry; A.S. Loginov Moscow Clinical Scientific Centre; Tver State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-6"><aff xml:lang="ru"><institution>Ильинская больница</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Ilyinsky Hospital</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-7"><aff xml:lang="ru"><institution>Московский государственный медико-стоматологический университет им. А.И. Евдокимова; Московский клинический научно-практический центр им. А.С. Логинова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>A.I. Yevdokimov Moscow State University of Medicine and Dentistry; A.S. Loginov Moscow Clinical Scientific Centre</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-8"><aff xml:lang="ru"><institution>Российская медицинская академия непрерывного профессионального образования; Городская клиническая больница им. С.П. Боткина</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian Medical Academy of Continuous Professional Education; Botkin Hospital</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>21</day><month>05</month><year>2023</year></pub-date><volume>26</volume><issue>2</issue><elocation-id>13048</elocation-id><permissions><copyright-statement>Copyright &amp;#x00A9; Шестакова М.В., Маев И.В., Аметов А.С., Анциферов М.Б., Бордин Д.С., Галстян Г.Р., Дзгоева Ф.Х., Кучерявый Ю.А., Мкртумян А.М., Никонова Т.В., Пашкова Е.Ю., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Шестакова М.В., Маев И.В., Аметов А.С., Анциферов М.Б., Бордин Д.С., Галстян Г.Р., Дзгоева Ф.Х., Кучерявый Ю.А., Мкртумян А.М., Никонова Т.В., Пашкова Е.Ю.</copyright-holder><copyright-holder xml:lang="en">Shestakova M.V., Maev I.V., Ametov A.S., Antsiferov M.B., Bordin D.S., Galstyan G.R., Dzgoeva F.K., Kucheryavyy Y.A., Mkrtumyan A.M., Nikonova T.V., Pashkova E.Y.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.dia-endojournals.ru/jour/article/view/13048">https://www.dia-endojournals.ru/jour/article/view/13048</self-uri><abstract><p>Сахарный диабет — заболевание как эндо-, так и экзокринной части поджелудочной железы. Экзокринная недостаточность поджелудочной железы при сахарном диабете может встречаться у каждого 2–3-го пациента и влиять не только на качество, но и на продолжительность жизни. При этом диагностике и лечению панкреатической недостаточности не уделяется должного внимания. Эндокринолог, как основной специалист, ведущий пациентов с сахарным диабетом наравне с гастроэнтерологом и терапевтом, может предположить наличие экзокринной недостаточности поджелудочной железы у пациента и самостоятельно принимать решение о ее коррекции с помощью заместительной ферментной терапии адекватными дозами.</p></abstract><trans-abstract xml:lang="en"><p>Diabetes is disease of both the endo- and exocrine parts of the pancreas. Pancreatic exocrine insufficiency (PEI) can occur in every 2–3 patients with diabetes and affect not only the quality, but also life expectancy. At the same time, the diagnosis and treatment of PEI is not getting enough attention. The endocrinologist, as the main specialist leading patients with diabetes, can diagnose and treat patients with pancreatic exocrine insufficiency and diabetes using adequate doses of pancreatic enzyme replacement therapy (PERT).</p></trans-abstract><kwd-group xml:lang="ru"><kwd>ферментная недостаточность</kwd><kwd>экзокринная недостаточность поджелудочной железы</kwd><kwd>ЭНПЖ</kwd><kwd>сахарный диабет</kwd><kwd>панкреатин</kwd><kwd>заместительная ферментная терапия</kwd><kwd>минимикросферы</kwd></kwd-group><kwd-group xml:lang="en"><kwd>pancreatic exocrine insufficiency</kwd><kwd>PEI</kwd><kwd>pancreatic enzyme replacement therapy</kwd><kwd>PERT</kwd><kwd>diabetes</kwd><kwd>pancreatin</kwd><kwd>minimicrospheres</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Работа выполнена по инициативе авторов без привлечения финансирования.</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Lindkvist B. 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