diaendoСахарный диабетDiabetes mellitus2072-03512072-0378Endocrinology research centre10.14341/DM13017diaendo-13017Research ArticleОригинальные исследованияOriginal StudiesINFLUENCE OF TYPE 2 SODIUM-GLUCOSE CO-TRANSPORTER INHIBITORS (DAPAGLIFLOZIN) ON THE INDICATORS OF TOTAL MORTALITY IN PATIENTS WITH TYPE 2 DIABETES (CARDIA-MOS STUDY, MOSCOW)https://orcid.org/0000-0002-9944-2997AntsiferovMikhail B.nadshul@gmail.comhttps://orcid.org/0000-0001-8289-0032DemidovNikolay A.nicolay13@mail.ruBalberovaMaria A.bode@cra-club.ruhttps://orcid.org/0000-0002-2196-8278LobanovaOlga V.shgb@zdrav.mos.ruhttps://orcid.org/0000-0002-0885-0371MudrikovaIrina G.gp219@zdrav.mos.ruhttps://orcid.org/0000-0001-8440-7809GusenbekovaDinara G.gp219@zdrav.mos.ruНациональный медицинский исследовательский центр эндокринологииРоссияЭндокринологический диспансерRussian FederationЩербинская городская больницаRussian FederationБольница КузнечикиRussian FederationГородская больница г. МосковскийRussian FederationГородская поликлиника № 219Russian Federation20220604202325513017Copyright © Antsiferov M.B., Demidov N.A., Balberova M.A., Lobanova O.V., Mudrikova I.G., Gusenbekova D.G., 20222022Antsiferov M.B., Demidov N.A., Balberova M.A., Lobanova O.V., Mudrikova I.G., Gusenbekova D.G.Antsiferov M.B., Demidov N.A., Balberova M.A., Lobanova O.V., Mudrikova I.G., Gusenbekova D.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.dia-endojournals.ru/jour/article/view/13017BACKGROUND

BACKGROUND: Widespread clinical use of drugs with cardioprotective/nephroprotective properties – particularly sodium-glucose cotransporter type 2 inhibitors (SGLT2i) – is based on results of large-scale international randomised trials. Meanwhile, there are no data demonstrating a potential effect of these drugs on mortality rates in real clinical practice in Russian patients. To address this lacuna, CARDIA-MOS study was conducted on a population of patients with type 2 diabetes (T2D) in Moscow.

OBJECTIVE

OBJECTIVE: To study the effect of SGLT2i on total mortality in T2D patients in Moscow.

MATERIALS AND METHODS

MATERIALS AND METHODS: To evaluate the frequency of different outcomes, two samples of patients were selected according to predetermined criteria: 1) patients who started SGLT2i (dapagliflozin) therapy in 2017; 2) a control group (no SGLT2i administration) matching the dapagliflozin group in terms of key indicators: age, T2D duration, cardiovascular diseases, insulin therapy, HbA1c level.

RESULTS

RESULTS: At Phase 1, data of 499 patients who started dapagliflozin treatment in 2017 were analysed against those of the 499 control group patients (n=998). The groups’ baseline characteristics were generally comparable. Pre-study SBP and HbA1c were worse in the dapagliflozin group. The use of dapagliflozin was associated with a 39% reduction in the relative risk of death from all causes (RR 0.614, 95% CI 0.417–0.903, p=0.013), led to a decrease in HbA1c levels by 0.8% (from 8.5 to 7.7%, p<0.001) over the 48-month-long observation.

CONCLUSION

CONCLUSION: The use of dapagliflozin in the treatment of T2D patients can reduce overall mortality and improve glycaemic control.

 

 

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The authors declare that there are no conflicts of interest present.