diaendoСахарный диабетDiabetes mellitus2072-03512072-0378Endocrinology research centre10.14341/DM12981diaendo-12981Research ArticleОбзорыReviewВзаимодействие воспаления и инсулиновой резистентности: молекулярные механизмы в инсулинопродуцирующих и инсулинозависимых тканяхThe interactions between inflammation and insulin resistance: molecular mechanisms in insulin-producing and insulin-dependent tissueshttps://orcid.org/0000-0002-2940-0230ЮдаеваА. Д.YudaevaA. D.

Юдаева Александра Дмитриевна

Researcher ID: GWN-0814-2022

Москва

Alexandra D. Yudaeva

Moscow

alexa.yudaeva@gmail.comhttps://orcid.org/0000-0003-3514-3936СтафеевЮ. С.StafeevI. S.

Стафеев Юрий Сергеевич - кандидат биологических наук; Researcher ID: O-2949-2015; Scopus Author ID: 57204688438.

121552, Москва, ул. 3-я Черепковская, д. 15А

Iurii S. Stafeev - PhD in Biology; Researcher ID: O-2949-2015; Scopus Author ID: 57204688438.

15A 3rd Cherepkovskaya street, 121552 Moscow

yuristafeev@gmail.comhttps://orcid.org/0000-0001-6027-2217МичуринаС. С.MichurinaS. S.

Мичурина Светлана Сергеевна; Scopus Author ID: 57202136814.

Москва

Svetlana S. Michurina; Scopus Author ID: 57202136814.

Moscow

michurinas192@gmail.comhttps://orcid.org/0000-0002-9949-0534МеньшиковМ. Ю.MenshikovM. Yu.

Меньшиков Михаил Юрьевич - доктор биологических наук; Researcher ID: O-2949-2015; Scopus Author ID: 6701418250.

Москва

Mikhail Yu. Menshikov - PhD in Biology; Researcher ID: O-2949-2015; Scopus Author ID: 6701418250.

Moscow

myumensh@mail.ruhttps://orcid.org/0000-0002-5057-127XШестаковаМ. В.ShestakovaM. V.

Шестакова Марина Владимировна - доктор медицинских наук, профессор, академик РАН; Researcher ID: D-9123-2012; Scopus Author ID: 7004195530.

Москва

Marina V. Shestakova - MD, PhD, Professor, Academician of the Russian Academy of Sciences; Researcher ID: D-9123-2012; Scopus Author ID: 7004195530.

Moscow

shestakova.mv@gmail.comhttps://orcid.org/0000-0002-0969-5780ПарфеноваЕ. В.ParfyonovaY. V.

Парфенова Елена Викторовна - доктор медицинских наук, профессор, член-корреспондент РАН; Researcher ID: B-9307-2014; Scopus Author ID: 57190312316.

Москва

Yelena V. Parfyonova - MD, PhD, Professor; Researcher ID: B-9307-2014; Scopus Author ID: 57190312316.

Moscow

yeparfyon@mail.ruНациональный медицинский исследовательский центр кардиологии им. академика Е.И. Чазова; Российский национальный исследовательский медицинский университет им. Н.И. ПироговаРоссияNational Medical Research Centre of Cardiology named after academician E.I.Chazov; Pirogov Russian National Research Medical UniversityRussian FederationНациональный медицинский исследовательский центр кардиологии им. академика Е.И. ЧазоваРоссияNational Medical Research Centre of Cardiology named after academician E.I.Chazov; Pirogov Russian National Research Medical UniversityRussian FederationНациональный медицинский исследовательский центр кардиологии им. академика Е.И. Чазова; Московский государственный университет им. М.В. ЛомоносоваРоссияNational Medical Research Centre of Cardiology named after academician E.I.Chazov; Lomonosov Moscow State UniversityRussian FederationНациональный медицинский исследовательский центр кардиологии им. академика Е.И. ЧазоваРоссияNational Medical Research Centre of Cardiology named after academician E.I.ChazovRussian FederationНациональный медицинский исследовательский центр эндокринологииРоссияEndocrinology Research CentreRussian Federation2023100220232617581Copyright © Юдаева А.Д., Стафеев Ю.С., Мичурина С.С., Меньшиков М.Ю., Шестакова М.В., Парфенова Е.В., 20232023Юдаева А.Д., Стафеев Ю.С., Мичурина С.С., Меньшиков М.Ю., Шестакова М.В., Парфенова Е.В.Yudaeva A.D., Stafeev I.S., Michurina S.S., Menshikov M.Y., Shestakova M.V., Parfyonova Y.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.dia-endojournals.ru/jour/article/view/12981

В современном мире распространенность ожирения и сахарного диабета 2 типа (СД2) существенно возрастает. В связи с этим также повышаются риски развития сопутствующих осложнений, в том числе метаболических и сердечно-сосудистых. Звеном взаимосвязи между ожирением и его осложнениями является воспалительный процесс как на клеточном уровне, так и на уровнях межклеточной коммуникации и внутриклеточных сигнальных каскадов. Механизм этой связи довольно сходный в поджелудочной железе и инсулинозависимых тканях: катализаторами процесса нередко являются различные липиды (холестерин, свободные жирные кислоты, триглицериды), которые способны активировать Толл-подобные рецепторы — рецепторы врожденного иммунитета, запускающие воспалительный процесс. Далее через активацию IKK- и JNK-зависимых сигнальных каскадов происходит секреция провоспалительных цитокинов — фактора некроза альфа, интерлейкинов (ИЛ-1β, ИЛ-6) и других, которые, действуя паракринно и аутокринно, поддерживают процесс воспаления как на локальном, так и на системном уровне. Таким образом, инсулинопродуцирующие и инсулинозависимые ткани, вовлеченные в процесс патогенеза СД2, через процесс воспаления интегрируются в патогенетический самоподдерживающийся цикл, который в конечном счете приводит к снижению секреции инсулина, гибели β-клеток поджелудочной железы и развитию инсулиновой резистентности.

In the modern world the prevalence of obesity and type 2 diabetes mellitus (T2DM) significantly increases. In this light the risks of obesity-associated complications also grow up. The crucial linkage between obesity and its metabolic and cardiovascular complications is inflammatory process. The mechanism of this linkage is similar in pancreas and insulin-dependent tissues both on cells, cell-to-cell communication and signaling pathway levels: the catalysts are different lipids (cholesterol, free fatty acids, triglycerides), which are able to activate Toll-like receptors of innate immunity and inflammation. Nextly, IKK- and JNK-dependent cascades activate the secretion of inflammatory cytokines TNFa, IL-1b, IL-6 and others, which act by paracrine and autocrine manner and support inflammation both in local and systemic levels. Thus, insulin-producing and insulin-dependent tissues, which are involved in T2DM pathogenesis, through the inflammatory process integrate in pathogenic and self-maintaining cycle, which leads to the suppression of insulin secretion, pancreatic β-cell failure and the development of insulin-dependent tissues insulin resistance.

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The authors declare that there are no conflicts of interest present.