diaendoСахарный диабетDiabetes mellitus2072-03512072-0378Endocrinology research centre10.14341/DM12948diaendo-12948Research ArticleОригинальные исследованияOriginal StudiesКардиометаболические факторы риска и особенности электрокардиограммы у пациентов c неинфицированными язвенными дефектами стопы и без них при сахарном диабете 2 типа: сравнительное исследованиеCardiometabolic risk factors and electrocardiogram results in type 2 diabetes patients with or without non-infected foot ulcers: A comparative studyhttps://orcid.org/0000-0002-5336-3353Al-NimerM.S.M.Al-NimerM.S.M.

Ваакуба, Васит

Marwan S.M. Al-Nimer - Bachelor of Medicine, Bachelor of Surgery, MD, PhD, Emeritus professor;; Researcher ID: 18036403100, Department of Pharmacology and Toxicology, University of Diyala; Department of Pharmacy, Al-Kut University College.

32001 Baqubah, Wasit

alnimermarwan@ymail.comhttps://orcid.org/0000-0001-8604-6082RathaR.RathaR.

Сулеймания

Rawa Ratha - Bachelor of Pharmacy, Master of Science, PhD, Senior Lecturer. Department of Clinical Pharmacy, College of Pharmacy, University of Sulaimani; Qaiwan International University, The Dean of Faculty of Pharmacy.

Sulaimani

rawaph@gmail.comУниверситет Диялы; Васитский университет колледжИракUniversity of Diyala; Al-Kut University CollegeIraqСулейманский университет; Кайванский международный университетИракCollege of Pharmacy, University of Sulaimani; Qaiwan International UniversityIraq2023100220232614954Copyright © Al-Nimer M., Ratha R., 20232023Al-Nimer M., Ratha R.Al-Nimer M., Ratha R.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.dia-endojournals.ru/jour/article/view/12948ОБОСНОВАНИЕ

ОБОСНОВАНИЕ. Многочисленные исследования показали, что сахарный диабет 2 типа (СД2) вызывает изменение параметров электрокардиограммы независимо от наличия патологии микрососудистого или макрососудистого русла.

ЦЕЛЬ

ЦЕЛЬ. Продемонстрировать различия в параметрах электрокардиограмм между пациентами с СД2 с неинфицированными диабетическими язвами стопы и пациентами с СД2 без язв.

МАТЕРИАЛЫ И МЕТОДЫ

МАТЕРИАЛЫ И МЕТОДЫ. Исследование проводилось в клинической больнице Шар в провинции Сулеймания в Ираке с июля 2018 г. по июнь 2019 г. 167 участников были распределены в три группы: в группу I (СД2, n=72), в группу II (СД2 с неинфицированными диабетическими язвами стопы, n=65) и в группу III (здоровые лица, n=30). Пациентам измеряли артериальное давление, регистрировали электрокардиограмму и оценивали антропометрические показатели. Гликемический и липидный профили в сыворотке крови натощак оценивались в рамках лабораторных тестов.

РЕЗУЛЬТАТЫ

РЕЗУЛЬТАТЫ. У пациентов II группы по сравнению с пациентами I группы зарегистрированы значимо более низкое диастолическое артериальное давление, более высокий индекс пульсового давления и более высокий уровень глюкозы в сыворотке крови натощак. У больных I группы отмечались значимо более высокая частота сердечных сокращений, укорочение интервала TQ и расширение дисперсии QRS. У пациентов II группы интервал TQ был значимо короче, чем у пациентов I группы (523,6±136,4 мс против 579,2±110,0 мс соответственно).

ЗАКЛЮЧЕНИЕ

ЗАКЛЮЧЕНИЕ. При неинфицированных язвах стоп интервал TQ, показатель нарушения реполяризации желудочков, намного короче и связан с высоким пульсовым давлением. Таким образом, изменения электрокардиограммы являются результатом сердечно-сосудистой вегетативной дисфункции.

BACKGROUND

BACKGROUND: Numerous investigations have demonstrated that type-2 diabetes (T2D) causes electrocardiographic alterations, whether or not there are microvascular or macrovascular problems.

AIM

AIM: With respect to glycemic control and the accompanying cardio-metabolic risk factors, the goal of this study was to demonstrate the variations in electrocardiogram records between T2D patients with non-infected diabetic foot ulcers (DFUs) and those without ulcers.

METHODS

METHODS: This study was performed in the Shar Teaching Hospital in the Sulaimani Governorate-Iraq from July 2018 to June 2019. 167 participants were grouped into Group I (T2D, n=72); Group II (T2D with non-infected diabetic foot ulcers, n=65) and Group III (healthy subjects, n= 30). Blood pressure, electrocardiography, and anthropometric measurements were taken. Fasting serum glucose and lipid profiles were assessed as part of laboratory tests.

RESULTS

RESULTS: Group II patients significantly differed from Group I by having lower diastolic blood pressure, a higher pulse pressure index, and a higher fasting serum glucose. The Group I patients had a significantly higher heart rate, a shortening of TQ-interval and widening of QRS dispersion. Group II patients had a significantly shorter TQ-interval compared with the corresponding value of Group I patients (523.6±136.4ms versus 579.2±110.0ms, respectively). These changes in the electrocardiograms are not related to the cardiometabolic risk factors.

CONCLUSION

CONCLUSION: In the non-infected diabetic foot, the TQ-interval, a measure of ventricular repolarization impairment, is much shorter and is linked to a broad pulse pressure. According to this finding, the electrocardiographic abnormalities are a result of cardiovascular autonomic dysfunction.

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The authors declare that there are no conflicts of interest present.