diaendoСахарный диабетDiabetes mellitus2072-03512072-0378Endocrinology research centre10.14341/DM12892diaendo-12892Research ArticleОригинальные исследованияOriginal StudiesСтруктурные особенности поджелудочной железы у пациентов с сахарным диабетом 1 типаStructurall features of the pancreas in patients with type 1 diabetes mellitushttps://orcid.org/0000-0002-4290-3182РагимовМ. Р.RagimovM. R.

Рагимов Магомедкерим Разинович, аспирант

117036, Москва, ул. Дм. Ульянова, д. 11

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Magomedkerim R. Ragimov, MD, PhD, student

11 Dm. Ulyanova street, 117036 Moscow

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tga.endocrine@gmail.comhttps://orcid.org/0000-0001-5656-2596НиконоваТ. В.NikonovaT. V.

Никонова Татьяна Васильевна, доктор медицинских наук

Москва

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Tatiana V. Nikonova, MD, PhD

Moscow

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tatiana_nikonova@mail.ruhttps://orcid.org/0000-0002-2812-7017БабаеваД. М.BabaevaD. M.

Бабаева Диана Мажлумовна, врач-рентгенолог

Москва

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Diana M. Babaeva, MD

Moscow

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dianababaeva1@yandex.ruhttps://orcid.org/0000-0002-7775-7568ВладимироваВ. П.VladimirovaV. P.

Владимирова Виктория Павловна, кандидат медицинских наук

Москва

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Victoria P. Vladimirova, MD, PhD

Moscow

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vpv970@gmail.comhttps://orcid.org/0000-0002-5057-127XШестаковаМ. В.ShestakovaM. V.

Шестакова Марина Владимировна, доктор медицинских наук, профессор, академик РАН

Москва

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Marina V. Shestakova, MD, PhD, Professor

Moscow

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shestakova.mv@gmail.comНациональный медицинский исследовательский центр эндокринологииРоссияEndocrinology Research CentreRussian Federation202208062022253239248Copyright © Рагимов М.Р., Никонова Т.В., Бабаева Д.М., Владимирова В.П., Шестакова М.В., 20222022Рагимов М.Р., Никонова Т.В., Бабаева Д.М., Владимирова В.П., Шестакова М.В.Ragimov M.R., Nikonova T.V., Babaeva D.M., Vladimirova V.P., Shestakova M.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.dia-endojournals.ru/jour/article/view/12892ОБОСНОВАНИЕ

ОБОСНОВАНИЕ. Наблюдения за изменениями объема и размеров поджелудочной железы (ПЖ) имеют давнюю историю, однако результаты исследований до сих пор не однозначны, не ясны конкретные причины данных изменений, а также их последствия. По некоторым данным, снижение объема ПЖ (ОПЖ) составляет 35–45% в популяции пациентов с длительным анамнезом сахарного диабета 1-го типа (СД1) и около 20–25% в течение первого года заболевания. Интересно, что при СД1 в 20–45% случаев отмечается развитие экзокринной недостаточности ПЖ, одним из проявлений которой является атрофия ПЖ, приводящая к снижению ОПЖ.

ЦЕЛЬ

ЦЕЛЬ. Оценить объемы и размеры ПЖ, а также факторы, способные влиять на их изменение.

МАТЕРИАЛЫ И МЕТОДЫ

МАТЕРИАЛЫ И МЕТОДЫ. В исследование были включены 78 пациентов с СД1, группу контроля составили 23 человека без ранее выявленных нарушений углеводного обмена, сопоставимые по возрасту и антропометрическим показателям с исследуемой группой. РЕЗУЛЬТАТЫ. Объем и размеры ПЖ были статистически значимо меньше у пациентов с СД1, чем в контрольной группе. Кроме того, доказано влияние длительности СД1 и возраста дебюта заболевания на данные показатели.

ЗАКЛЮЧЕНИЕ

ЗАКЛЮЧЕНИЕ. Объем и размеры ПЖ у пациентов с СД1 меньше, чем у здоровых лиц. Необходимо изучение влияния этих изменений на функцию ПЖ.

BACKGROUND

BACKGROUND: Observation of changes in the volume and size of the pancreas has a long history, however, the results of studies are still not unambiguous, the specific causes of changes in pancreatic volume, as well as their consequences, are not clear. According to some data, the decrease of pancreas volume in life expectancy is 35–45% in the population of patients with a long history of type 1 diabetes, and about 20–25% during the first year of the disease. Interestingly, in T1D in 20–45% of cases, the development of exocrine pancreatic insufficiency is noted, one of the manifestations of which is pancreatic atrophy, leading to a decrease in life expectancy.

AIM

AIM: Assess the volume and size of the pancreas, as well as factors that can influence on their changes.

MATERIALS AND METHODS

MATERIALS AND METHODS: The study included 78 patients with type 1 diabetes mellitus, the control group consisted of 23 people without previously identified disorders of carbohydrate metabolism, comparable in age and anthropometric parameters with the study group. RESULTS: The volume and dimensions of the pancreas were statistically significantly less in patients with T1D than in the control group. In addition, the influence of the duration of T1D and the age of onset of the disease on these indicators has been proven.

CONCLUSION

CONCLUSION: The volume and size of the pancreas in patients with T1D is less than in healthy individuals. It is necessary to  study the effect of these changes on the function of the pancreas.

 

 

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The authors declare that there are no conflicts of interest present.