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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">diaendo</journal-id><journal-title-group><journal-title xml:lang="ru">Сахарный диабет</journal-title><trans-title-group xml:lang="en"><trans-title>Diabetes mellitus</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-0351</issn><issn pub-type="epub">2072-0378</issn><publisher><publisher-name>Endocrinology research centre</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14341/DM12785</article-id><article-id custom-type="elpub" pub-id-type="custom">diaendo-12785</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Оригинальные исследования</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Original Studies</subject></subj-group></article-categories><title-group><article-title>Влияние COVID-19-инфекции на развитие сахарного диабета 1 типа у детей и подростков</article-title><trans-title-group xml:lang="en"><trans-title>Impact of COVID-19 infection on the development of type 1 diabetes mellitus in children and adolescents</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0926-0306</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хайдарова</surname><given-names>Ф. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Khaydarova</surname><given-names>F. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Хайдарова Феруза Алимовна - доктор медицинских наук, профессор.</p><p>Ташкент</p></bio><bio xml:lang="en"><p>Feruza A. Khaydarova - MD, PhD, Professor.</p><p>Tashkent</p></bio><email xlink:type="simple">alimovna@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4921-4494</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Алимова</surname><given-names>Н. У.</given-names></name><name name-style="western" xml:lang="en"><surname>Alimova</surname><given-names>N. U.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Алиева Анна Валерьевна - доктор медицинских наук; Researcher ID: AAK-1734-2020; Scopus Author ID: 57222066832; eLibrary SPIN: 5700-6089/</p><p>100125, Ташкент, ул. Мирзо Улугбека, 56</p></bio><bio xml:lang="en"><p>Nasiba U. Alimova - PhD.</p><p>Tashkent</p></bio><email xlink:type="simple">annaalieva@yahoo.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4921-4494</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Алиева</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Alieva</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Алиева Анна Валерьевна - доктор медицинских наук; Researcher ID: AAK-1734-2020; Scopus Author ID: 57222066832; eLibrary SPIN: 5700-6089.</p><p>100125, Ташкент, ул. Мирзо Улугбека, 56</p></bio><bio xml:lang="en"><p>Anna V. Alieva - MD, PhD; Researcher ID: AAK-1734-2020; Scopus Author ID: 57222066832; eLibrary SPIN: 5700-6089</p><p>56, M.Ulugbek str., 100125, Tashkent</p></bio><email xlink:type="simple">annaalieva@yahoo.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4708-0306</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Садыкова</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Sadykova</surname><given-names>A. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Садикова Акида Саттаровна - доктор медицинских наук.</p><p>Ташкент</p></bio><bio xml:lang="en"><p>Akida S. Sadikova – PhD.</p><p>Tashkent</p></bio><email xlink:type="simple">akidahon@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4683-1435</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Арипова</surname><given-names>М. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Aripova</surname><given-names>M. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Арипова Малика Дильшадовна</p><p>Ташкент</p></bio><bio xml:lang="en"><p>Malika D. Aripova – MD.</p><p>Tashkent</p></bio><email xlink:type="simple">Dr.Aripova@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Республиканский специализированный научно-практический медицинский центр эндокринологии им. академика Я.Х. Туракулова</institution><country>Узбекистан</country></aff><aff xml:lang="en"><institution>Republican Specialized Scientific-Practical Medical Centre of Endocrinology named after academician Ya.Kh. Turakulov</institution><country>Uzbekistan</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>22</day><month>03</month><year>2022</year></pub-date><volume>25</volume><issue>1</issue><fpage>21</fpage><lpage>26</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Хайдарова Ф.А., Алимова Н.У., Алиева А.В., Садыкова А.С., Арипова М.Д., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Хайдарова Ф.А., Алимова Н.У., Алиева А.В., Садыкова А.С., Арипова М.Д.</copyright-holder><copyright-holder xml:lang="en">Khaydarova F.A., Alimova N.U., Alieva A.V., Sadykova A.S., Aripova M.D.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.dia-endojournals.ru/jour/article/view/12785">https://www.dia-endojournals.ru/jour/article/view/12785</self-uri><abstract><p>Пандемия COVID-19 не обошла стороной и детей. Хотя в целом течение вирусной инфекции у детей происходит в легкой форме, остается актуальным вопрос об отдаленных последствиях COVID-19 в детском и подростковом возрасте, в частности, о возможном влиянии на бета-клетки поджелудочной железы.</p><sec><title>Цель</title><p>Цель. Изучить клинические особенности сахарного диабета у детей, выявленного впервые после перенесенной COVID-19-инфекции.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. В данной статье приведены предварительные результаты, полученные при обследовании детей и подростков в клинике РСНПМЦЭ с первые выявленным сахарным диабетом после перенесенной COVID-­инфекции, также представлены систематический обзор и подборка из 61 клинического случая (исследование серии случаев).</p></sec><sec><title>Результаты</title><p>Результаты. Из 120 детей, госпитализированных в клинику РСНПМЦЭ с впервые выявленным диабетом, у 15 он был выявлен после перенесенной инфекции COVID-19, у всех в состоянии диабетического кетоацидоза. Только 20% детей знали о перенесенной инфекции COVID-19, течение было в легкой форме, у 80% детей инфекция протекала бессимптомно. У всех детей на момент выявления были высокий уровень гликированного гемоглобина — выше 10%, низкий уровень витамина D, высокие уровни антител к SARS-CoV-2 (IgG), потребность в инсулине выше средней.</p></sec><sec><title>Заключение</title><p>Заключение. Вирус SARS-CoV-2 мог стать непосредственной причиной развития сахарного диабета у детей даже при бессимптомном течении вирусной инфекции. Однако остается открытым вопрос о точной классификации диабета, возникшего после COVID-19 у детей. Необходимо проводить информирование населения о первых признаках и симптомах сахарного диабета с целью своевременного обращения к врачу для диагностики заболевания.</p></sec></abstract><trans-abstract xml:lang="en"><p>Children did not escape the COVID-19 pandemic. Although, in general, the course of viral infection in children is mild, the question of the long-term effects of COVID-19 on a child and adolescent, in particular, on pancreatic beta cells, remains unclear.</p><sec><title>Аim</title><p>Аim: Тo study the characteristics of children with diabetes mellitus identified after COVID-19 infection.</p></sec><sec><title>Materials and methods</title><p>Materials and methods: This article presents the preliminary results obtained from children and adolescents hospitalized at the RSSPMCE clinic with the newly diagnosed diabetes mellitus after COVID infection, as well as a systematic review of 61 clinical cases (case series study).</p></sec><sec><title>Results</title><p>Results: Of the 120 children hospitalized at the RSSPMCE clinic with newly diagnosed diabetes, 15 were diagnosed with diabetes after COVID-19 infection, all in a state of diabetic ketoacidosis. Only 20% of children knew about the previous COVID-19 infection, the course of the disease was mild, in 80% of children the infection was asymptomatic. At the time of diabetes onset, all children had a high level of HbA1c - above 10%, a low level of vitamin D, high levels of antibodies to SARS-CoV-2 (IgG), and the need for insulin was above the average.</p></sec><sec><title>Conclusion</title><p>Conclusion: The SARS CoV-2 virus could be the direct cause of the development of diabetes mellitus in children, even with the asymptomatic course of the viral infection. However, the question remains about the exact classification of diabetes after COVID-19 in children. It is necessary to inform the population about the first signs and symptoms of diabetes mellitus in order to timely consult a doctor for the diagnosis of diabetes mellitus.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>дети и подростки</kwd><kwd>сахарный диабет</kwd><kwd>коронавирусная инфекция</kwd><kwd>COVID-19</kwd></kwd-group><kwd-group xml:lang="en"><kwd>children and adolescents</kwd><kwd>diabetes mellitus</kwd><kwd>coronavirus infection</kwd><kwd>COVID-19</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Данная работа проведена в рамках гранта Министерства инновации Республики Узбекистана №А-СС-2021-139 «Разработка алгоритмов диагностики, профилактики и лечения COVID-19 и его осложнений при гипергликемических состояниях и сахарном диабете»</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Ludvigsson JF. 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