diaendoСахарный диабетDiabetes mellitus2072-03512072-0378Endocrinology research centre10.14341/DM12502diaendo-12502Research ArticleОбзорыReviewРоль показателей обмена железа в прогнозировании гестационного сахарного диабетаThe role of iron metabolism indicators in predicting gestational diabetes mellitushttps://orcid.org/0000-0003-3403-1895ТоросянА. О.TorosyanA. O.

Торосян Айарпи Овсеповна, аспирант

117198, г. Москва, ул. Миклухо-Маклая, д. 6

eLibrary SPIN: 5278-5585 

Ayarpi O. Torosyan, PhD student

6, Miklukho-Maklaya street, 117198 Moscow

eLibrary SPIN: 5278-5585 

dr.arev@gmail.comhttps://orcid.org/0000-0003-0274-1729ЛогиноваЕ. В.LoginovaE. V.

Логинова Екатерина Владимировна, аспирант

SPIN: 2818-8941 

Москва

Ekaterina V. Loginova, PhD student

SPIN: 2818-8941 

Moscow

katya.loginova@mail.ruhttps://orcid.org/0000-0001-7213-5981ГагаевЧ. Г.GagaevC. G.

Гагаев Челеби Гасанович, д.м.н., профессор

eLibrary SPIN: 7414-7080

Москва

Chelebi G. Gagaev, MD, PhD, Professor

eLibrary SPIN: 7414-7080 

Moscow

gasanovich@gmail.comРоссийский университет дружбы народовРоссияPeoples’ Friendship University of RussiaRussian Federation202109102021244365370Copyright © Торосян А.О., Логинова Е.В., Гагаев Ч.Г., 20212021Торосян А.О., Логинова Е.В., Гагаев Ч.Г.Torosyan A.O., Loginova E.V., Gagaev C.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.dia-endojournals.ru/jour/article/view/12502

Как дефицит железа (Fe), так и гипергликемия широко распространены во всем мире среди беременных женщин. По последним данным Американской ассоциации диабета (ADA), распространенность гестационного сахарного диабета (ГСД) возросла и достигает 15–20%. В настоящее время появляется все больше доказательств того, что существует связь между метаболизмом Fe и гомеостазом глюкозы. Изучение изменений показателей обмена Fe в сыворотке беременных с нарушением толерантности к глюкозе и ГСД играет важную роль в расширении понимания патогенеза данных состояний. Гипотеза о том, что избыток Fe повышает риск развития ГСД, побудила нас выполнить обзор и оценить потенциальную связь между повышенным уровнем Fe и риском развития ГСД. Цель — обобщить имеющиеся данные о корреляции статуса Fe в организме с ГСД. Становится все более общепризнанным, что избыточное накопление Fe связано с повышенным риском диабета. Данные о взаимосвязи между сывороточным ферритином и ГСД в российской популяции отсутствуют, тогда как раннее выявление риска развития ГСД будет иметь большое значение для предотвращения заболевания и связанных с ним последствий для здоровья. Роль статуса Fe в качестве биомаркера ГСД в популяциях высокого риска представляет собой интерес как для прогностических и диагностических мероприятий, так и для терапевтических вмешательств. Для лучшего понимания того, увеличивает ли избыток Fe риск развития ГСД, необходимы исследования, которые раскроют роль Fe в механизмах развития ГСД.

Iron (Fe) deficiency and hyperglycaemia are both widely found throughout the world among pregnant women. According to the latest data from the American Diabetes Association (ADA), the prevalence of gestational diabetes mellitus (GDM) has increased and reaches 15–20%. Nowadays, there is growing evidence that a link between Fe metabolism and glucose homeostasis exists. The study of changes in the indicators of Fe metabolism in the serum of pregnant women with glucose intolerance and GDM plays an important role in expanding the understanding of the pathogenesis of these conditions. The hypothesis that excess Fe increases the risk of developing GDM has prompted us to review and evaluate the potential relationship between elevated Fe levels and the risk of developing GDM. The aim is to integrate all available data on the correlation between GDM and Fe status in the body. It is increasingly being recognised that excess Fe accumulation in the body is associated with an increased risk of diabetes. There is no available data on the relationship between serum ferritin and GDM in the Russian population, while early identification of the risk of GDM development will be of great importance for its related health effects and prevention. The role of Fe status as a GDM biomarker in high-risk populations is of interest, both for prognostic and diagnostic measures, and for therapeutic interventions. For a better understanding of whether an excess of Fe increases the risk of developing GDM, studies are needed to reveal the role of Fe in the mechanisms of GDM development.

гестационный сахарный диабетжелезоферритингемоглобингепсидинфакторы рискаgestational diabetesironferritinhaemoglobinhepcidinrisk factorsReferencesAmiri FN, Basirat Z, Omidvar S, et al. Comparison of the serum iron, ferritin levels and total iron-binding capacity between pregnant women with and without gestational diabetes. J Nat Sc Biol Med. 2013;4:302-305. doi: https://doi.org/10.4103/0976-9668.116977Amiri FN, Basirat Z, Omidvar S, et al. Comparison of the serum iron, ferritin levels and total iron-binding capacity between pregnant women with and without gestational diabetes. J Nat Sc Biol Med. 2013;4:302-305. doi: https://doi.org/10.4103/0976-9668.116977Wang Z, Fan H, Yang W, et al. Correlation between plasma ferritin level and gestational diabetes mellitus and its impact on fetal macrosomia. J Diabetes Investig. 2018;9:1354-1359. doi: https://doi.org/10.1111/jdi.12836Wang Z, Fan H, Yang W, et al. Correlation between plasma ferritin level and gestational diabetes mellitus and its impact on fetal macrosomia. J Diabetes Investig. 2018;9:1354-1359. doi: https://doi.org/10.1111/jdi.12836Standards of medical care in diabetes-2017. American Diabetes Association. Diabetes Care. 2017;40:S11-S24.Standards of medical care in diabetes-2017. American Diabetes Association. Diabetes Care. 2017;40:S11-S24.Fu S, Li F, Zhou J, Liu Z. The relationship between body iron status, iron intake and gestational diabetes: A systematic review and meta‐analysis. Medicine. 2016;95(2):e2383. doi: https://doi.org/10.1097/MD.0000000000002383Fu S, Li F, Zhou J, Liu Z. The relationship between body iron status, iron intake and gestational diabetes: A systematic review and meta‐analysis. Medicine. 2016;95(2):e2383. doi: https://doi.org/10.1097/MD.0000000000002383Zein S, Rachidi S, Hininger-Favier I. Is oxidative stress induced by iron status associated with gestational diabetes mellitus? J. Trace Elem. Med. Biol. 2014;28:65-69. doi: https://doi.org/10.1016/j.jtemb.2013.09.009Zein S, Rachidi S, Hininger-Favier I. Is oxidative stress induced by iron status associated with gestational diabetes mellitus? J. Trace Elem. Med. Biol. 2014;28:65-69. doi: https://doi.org/10.1016/j.jtemb.2013.09.009Wang Y, Tan M, Huang Z, et al. Elemental contents in serum of pregnant women with gestational diabetes mellitus. Biol. Trace Elem. Res. 2002;88:113-118. doi: https://doi.org/10.1385/BTER:88:2:113Wang Y, Tan M, Huang Z, et al. Elemental contents in serum of pregnant women with gestational diabetes mellitus. Biol. Trace Elem. Res. 2002;88:113-118. doi: https://doi.org/10.1385/BTER:88:2:113Zein S, Rachidi S, Awada S, et al. High iron level in early pregnancy increased glucose intolerance. JTEMB. 2015;30:220-225. doi: https://doi.org/10.1016/j.jtemb.2014.09.004Zein S, Rachidi S, Awada S, et al. High iron level in early pregnancy increased glucose intolerance. JTEMB. 2015;30:220-225. doi: https://doi.org/10.1016/j.jtemb.2014.09.004Cheng Y, Li T, He M, et al. The association of elevated serum ferritin concentration in early pregnancy with gestational diabetes mellitus: a prospective observational study. Eur J Clin Nutr. 2020;74(5):741-748. doi: https://doi.org/10.1038/s41430-019-0542-6Cheng Y, Li T, He M, et al. The association of elevated serum ferritin concentration in early pregnancy with gestational diabetes mellitus: a prospective observational study. Eur J Clin Nutr. 2020;74(5):741-748. doi: https://doi.org/10.1038/s41430-019-0542-6Khambalia AZ, Aimone A, Nagubandi P, et al. High maternal iron status, dietary iron intake and iron supplement use in pregnancy and risk of gestational diabetes mellitus: a prospective study and systematic review. Diabet Med. 2016;33(9):1211-21. doi: https://doi.org/10.1111/dme.13056Khambalia AZ, Aimone A, Nagubandi P, et al. High maternal iron status, dietary iron intake and iron supplement use in pregnancy and risk of gestational diabetes mellitus: a prospective study and systematic review. Diabet Med. 2016;33(9):1211-21. doi: https://doi.org/10.1111/dme.13056Amiri FN, Basirat Z, Omidvar S, et al. Comparison of the serum iron, ferritin levels and total iron-binding capacity between pregnant women with and without gestational diabetes. J Nat Sci Biol Med. 2013;4:302-305. doi: https://doi.org/10.4103/0976-9668.116977Amiri FN, Basirat Z, Omidvar S, et al. Comparison of the serum iron, ferritin levels and total iron-binding capacity between pregnant women with and without gestational diabetes. J Nat Sci Biol Med. 2013;4:302-305. doi: https://doi.org/10.4103/0976-9668.116977Kinnunen TI, Luoto R, Helin A, Hemminki E. Supplemental iron intake and the risk of glucose intolerance in pregnancy: Re-analysis of a randomised controlled trial in Finland. Matern Child Nutr. 2016;12(1):74-84. doi: https://doi.org/10.1111/mcn.12139Kinnunen TI, Luoto R, Helin A, Hemminki E. Supplemental iron intake and the risk of glucose intolerance in pregnancy: Re-analysis of a randomised controlled trial in Finland. Matern Child Nutr. 2016;12(1):74-84. doi: https://doi.org/10.1111/mcn.12139Fernández-Cao JC, Aranda N, Ribot B, et al. Elevated iron status and risk of gestational diabetes mellitus: A systematic review and meta‐analysis. Matern Child Nutr. 2017;13(4):e12400. doi: https://doi.org/10.1111/mcn.12400Fernández-Cao JC, Aranda N, Ribot B, et al. Elevated iron status and risk of gestational diabetes mellitus: A systematic review and meta‐analysis. Matern Child Nutr. 2017;13(4):e12400. doi: https://doi.org/10.1111/mcn.12400Powe CE. Early Pregnancy Biochemical Predictors of Gestational Diabetes Mellitus. Curr Diab Rep. 2017; 17(2):12. doi: https://doi.org/10.1007/s11892-017-0834-yPowe CE. Early Pregnancy Biochemical Predictors of Gestational Diabetes Mellitus. Curr Diab Rep. 2017; 17(2):12. doi: https://doi.org/10.1007/s11892-017-0834-yKataria Y, Wu Y, Horskjær PH, et al. Iron Status and Gestational Diabetes — A Meta-Analysis. Nutrients. 2018;(10):621. doi: https://doi.org/10.3390/nu10050621Kataria Y, Wu Y, Horskjær PH, et al. Iron Status and Gestational Diabetes — A Meta-Analysis. Nutrients. 2018;(10):621. doi: https://doi.org/10.3390/nu10050621Zhang C, Rawal S. Dietary iron intake, iron status, and gestational diabetes. Am J Clin Nutr. 2017;106(6):1672S-1680S. doi: https://doi.org/10.3945/ajcn.117.156034Zhang C, Rawal S. Dietary iron intake, iron status, and gestational diabetes. Am J Clin Nutr. 2017;106(6):1672S-1680S. doi: https://doi.org/10.3945/ajcn.117.156034Zhuang T, Han H, Yang Z. Iron, Oxidative Stress and Gestational Diabetes. Nutrients. 2014;6:3968-3980. doi: https://doi.org/10.3390/nu6093968Zhuang T, Han H, Yang Z. Iron, Oxidative Stress and Gestational Diabetes. Nutrients. 2014;6:3968-3980. doi: https://doi.org/10.3390/nu6093968Lao TT, Tam KF. Maternal serum ferritin and gestational impaired glucose tolerance. Diabetes Care. 1997;20(9):1368-1369. doi: https://doi.org/10.2337/diacare.20.9.1368Lao TT, Tam KF. Maternal serum ferritin and gestational impaired glucose tolerance. Diabetes Care. 1997;20(9):1368-1369. doi: https://doi.org/10.2337/diacare.20.9.1368Lao TT, Ho LF. Impact of iron deficiency anemia on prevalence of gestational diabetes mellitus. Diabetes Care. 2004;27(3):650-656. doi: https://doi.org/10.2337/diacare.27.3.650Lao TT, Ho LF. Impact of iron deficiency anemia on prevalence of gestational diabetes mellitus. Diabetes Care. 2004;27(3):650-656. doi: https://doi.org/10.2337/diacare.27.3.650Lao TT, Chan LY, Tam KF, Ho LF. Maternal hemoglobin and risk of gestational diabetes mellitus in chinese women. Obstet Gynecol. 2002;99:807-812. doi: https://doi.org/10.1016/s0029-7844(02)01941-5Lao TT, Chan LY, Tam KF, Ho LF. Maternal hemoglobin and risk of gestational diabetes mellitus in chinese women. Obstet Gynecol. 2002;99:807-812. doi: https://doi.org/10.1016/s0029-7844(02)01941-5Behboudi-Gandevani S, Safary K, Moghaddam-Banaem L, et al. The relationship between maternal serum iron and zinc levels and their nutritional intakes in early pregnancy with gestational diabetes. Biol Trace Elem Res. 2013;154:7-13. doi: https://doi.org/10.1007/s12011-013-9703-yBehboudi-Gandevani S, Safary K, Moghaddam-Banaem L, et al. The relationship between maternal serum iron and zinc levels and their nutritional intakes in early pregnancy with gestational diabetes. Biol Trace Elem Res. 2013;154:7-13. doi: https://doi.org/10.1007/s12011-013-9703-yBowers KA, Olsen SF, Bao W, et al. Plasma concentrations of ferritin in early pregnancy are associated with risk of gestational diabetes mellitus in women in the Danish national birth cohort. J Nutr. 2016;146:1756-1761. doi: https://doi.org/10.3945/jn.115.227793Bowers KA, Olsen SF, Bao W, et al. Plasma concentrations of ferritin in early pregnancy are associated with risk of gestational diabetes mellitus in women in the Danish national birth cohort. J Nutr. 2016;146:1756-1761. doi: https://doi.org/10.3945/jn.115.227793Zhao L, Lian J, Tian J, et al. Dietary intake of heme iron and body iron status are associated with the risk of gestational diabetes mellitus: a systematic review and meta-analysis. Asia Pac J Clin Nutr. 2017; 26(6):1092-1106. doi: https://doi.org/10.6133/apjcn.022017.09Zhao L, Lian J, Tian J, et al. Dietary intake of heme iron and body iron status are associated with the risk of gestational diabetes mellitus: a systematic review and meta-analysis. Asia Pac J Clin Nutr. 2017; 26(6):1092-1106. doi: https://doi.org/10.6133/apjcn.022017.09Afkhami-Ardekani M, Rashidi M. Iron status in women with and without gestational diabetes mellitus. J Diabetes Complications. 2009;23:194-198. doi: https://doi.org/10.1016/j.jdiacomp.2007.11.006Afkhami-Ardekani M, Rashidi M. Iron status in women with and without gestational diabetes mellitus. J Diabetes Complications. 2009;23:194-198. doi: https://doi.org/10.1016/j.jdiacomp.2007.11.006Chen X, Scholl TO, Stein TP. Association of elevated serum ferritin levels and the risk of gestational diabetes mellitus in pregnant women: The camden study. Diabetes Care. 2006;29:1077-1082. doi: https://doi.org/10.2337/dc06-0164Chen X, Scholl TO, Stein TP. Association of elevated serum ferritin levels and the risk of gestational diabetes mellitus in pregnant women: The camden study. Diabetes Care. 2006;29:1077-1082. doi: https://doi.org/10.2337/dc06-0164Soubasi V, Petridou S, Sarafidis K, et al. Association of increased maternal ferritin levels with gestational diabetes and intra-uterine growth retardation. Diabetes & Metabolism. 2010;36:58-63. doi: https://doi.org/10.1016/j.diabet.2009.06.010Soubasi V, Petridou S, Sarafidis K, et al. Association of increased maternal ferritin levels with gestational diabetes and intra-uterine growth retardation. Diabetes & Metabolism. 2010;36:58-63. doi: https://doi.org/10.1016/j.diabet.2009.06.010Lao TT, Chan PL, Tam KF. Gestational diabetes mellitus in the last trimester – a feature of maternal iron excess? Diabetic Med. 2001;18:218-223. doi: https://doi.org/10.1046/j.1464-5491.2001.00453.xLao TT, Chan PL, Tam KF. Gestational diabetes mellitus in the last trimester – a feature of maternal iron excess? Diabetic Med. 2001;18:218-223. doi: https://doi.org/10.1046/j.1464-5491.2001.00453.xYadav A, Saini V, Kataria M, Jain A. Need of iron supplementation in gestational diabetes mellitus. Acta Endocrinologica. 2017;XIII(1):126-128. doi: https://doi.org/10.4183/aeb.2017.126Yadav A, Saini V, Kataria M, Jain A. Need of iron supplementation in gestational diabetes mellitus. Acta Endocrinologica. 2017;XIII(1):126-128. doi: https://doi.org/10.4183/aeb.2017.126Rawal S, Hinkle SN, Bao W, et al. A longitudinal study of body iron status during pregnancy and risk of gestational diabetes: findings from a prospective, multiracial cohort. Diabetologia. 2017;60(2):249-257. doi: https://doi.org/10.1007/s00125-016-4149-3Rawal S, Hinkle SN, Bao W, et al. A longitudinal study of body iron status during pregnancy and risk of gestational diabetes: findings from a prospective, multiracial cohort. Diabetologia. 2017;60(2):249-257. doi: https://doi.org/10.1007/s00125-016-4149-3Al-Saleh E, Nandakumaran M, Al-Shammari M, Al-Harouny A. Maternal-fetal status of copper, iron, molybdenum, selenium, and zinc in patients with gestational diabetes. J Matern Fetal Neonatal Med. 2004;16:15-21. doi: https://doi.org/10.1080/14767050412331283139Al-Saleh E, Nandakumaran M, Al-Shammari M, Al-Harouny A. Maternal-fetal status of copper, iron, molybdenum, selenium, and zinc in patients with gestational diabetes. J Matern Fetal Neonatal Med. 2004;16:15-21. doi: https://doi.org/10.1080/14767050412331283139Yeniel AO, Ergenoglu AM, Sanhal CY, et al. Does high maternal first trimester iron status have an effect on the 50 g oral glucose test? J Obstet Gynaecol. 2012;32:332-334. doi: https://doi.org/10.3109/01443615.2012.658894Yeniel AO, Ergenoglu AM, Sanhal CY, et al. Does high maternal first trimester iron status have an effect on the 50 g oral glucose test? J Obstet Gynaecol. 2012;32:332-334. doi: https://doi.org/10.3109/01443615.2012.658894Akhlaghi F, Bagheri SM, Rajabi O. A comparative study of relationship between micronutrients and gestational diabetes. ISRN Obstet Gynecol. 2012;2012(470419). doi: https://doi.org/10.5402/2012/470419 32.Akhlaghi F, Bagheri SM, Rajabi O. A comparative study of relationship between micronutrients and gestational diabetes. ISRN Obstet Gynecol. 2012;2012(470419). doi: https://doi.org/10.5402/2012/470419 32.Yang A, Zhao J, Lu M, et al. Expression of Hepcidin and Ferroportin in the Placenta, and Ferritin and Transferrin Receptor 1 Levels in Maternal and Umbilical Cord Blood in Pregnant Women with and without Gestational Diabetes. Int J Environ Res Public Health. 2016;13(766). doi: https://doi.org/10.3390/ijerph13080766Yang A, Zhao J, Lu M, et al. Expression of Hepcidin and Ferroportin in the Placenta, and Ferritin and Transferrin Receptor 1 Levels in Maternal and Umbilical Cord Blood in Pregnant Women with and without Gestational Diabetes. Int J Environ Res Public Health. 2016;13(766). doi: https://doi.org/10.3390/ijerph13080766Derbent AU, Simavli SA, Kaygusuz I, et al. Serum hepcidin is associated with parameters of glucose metabolism in women with gestational diabetes mellitus. J. Matern. Fetal Neonatal Med. 2013;26:1112-1115. doi: https://doi.org/10.3109/14767058.2013.770462Derbent AU, Simavli SA, Kaygusuz I, et al. Serum hepcidin is associated with parameters of glucose metabolism in women with gestational diabetes mellitus. J. Matern. Fetal Neonatal Med. 2013;26:1112-1115. doi: https://doi.org/10.3109/14767058.2013.770462Маянский Н.А., Семикина Е.Л. Гепцидин: основной регулятор обмена железа и новый диагностический маркер // Вопросы диагностики в педиатрии. — 2009. — №1. — С. 18–23. [Majanskij NA, Semikina EL. Gepcidin: osnovnoj reguljator obmena zheleza i novyj diagnosticheskij marker. Voprosy diagnostiki v pediatrii. 2009;1:18-23. (In Russ.)].Маянский Н.А., Семикина Е.Л. Гепцидин: основной регулятор обмена железа и новый диагностический маркер // Вопросы диагностики в педиатрии. — 2009. — №1. — С. 18–23. [Majanskij NA, Semikina EL. Gepcidin: osnovnoj reguljator obmena zheleza i novyj diagnosticheskij marker. Voprosy diagnostiki v pediatrii. 2009;1:18-23. (In Russ.)].Саприна Т.В., Зима А.П., Мусина Н.Н., и др. Патогенетические аспекты нарушения метаболизма гепсидина и феррокинетики при патологии углеводного обмена // Сахарный диабет. — 2018. — Т. 21. — №6. — С. 506-512. [Saprina TV, Zima AP, Musina NN, et al. Pathogenetic aspects of hepcidin metabolism and ferrocinetics dysregulation in carbohydrate metabolism disorders. Diabetes Mellitus. 2018;21(6):506-512 (In Russ.)]. doi: https://doi.org/10.14341/DM9378Саприна Т.В., Зима А.П., Мусина Н.Н., и др. Патогенетические аспекты нарушения метаболизма гепсидина и феррокинетики при патологии углеводного обмена // Сахарный диабет. — 2018. — Т. 21. — №6. — С. 506-512. [Saprina TV, Zima AP, Musina NN, et al. Pathogenetic aspects of hepcidin metabolism and ferrocinetics dysregulation in carbohydrate metabolism disorders. Diabetes Mellitus. 2018;21(6):506-512 (In Russ.)]. doi: https://doi.org/10.14341/DM9378Cauza E, Hanusch-Enserer U, Bischof M, et al. Increased c282y heterozygosity in gestational diabetes. Fetal Diagn Ther. 2005;20:349-354. doi: https://doi.org/10.1159/000086811Cauza E, Hanusch-Enserer U, Bischof M, et al. Increased c282y heterozygosity in gestational diabetes. Fetal Diagn Ther. 2005;20:349-354. doi: https://doi.org/10.1159/000086811Bencaiova G, Krafft A, Burkhardt T, Zimmermann R. Hemoglobinopathies, body iron stores and gestational diabetes mellitus. Haematologica. 2005;90:1138-1139.Bencaiova G, Krafft A, Burkhardt T, Zimmermann R. Hemoglobinopathies, body iron stores and gestational diabetes mellitus. Haematologica. 2005;90:1138-1139.Backe MB, Moen IW, Ellervik C, et al. Iron regulation of pancreatic beta-cell functions and oxidative stress. Ann Rev Nutr. 2016;36:241-273. doi: https://doi.org/10.1146/annurev-nutr-071715-050939Backe MB, Moen IW, Ellervik C, et al. Iron regulation of pancreatic beta-cell functions and oxidative stress. Ann Rev Nutr. 2016;36:241-273. doi: https://doi.org/10.1146/annurev-nutr-071715-050939Dongiovanni P, Ruscica M, Rametta R, et al. Dietary iron overload induces visceral adipose tissue insulin resistance. Am J Pathol. 2013;182(6):2254-2263. doi: https://doi.org/10.1016/j.ajpath.2013.02.019Dongiovanni P, Ruscica M, Rametta R, et al. Dietary iron overload induces visceral adipose tissue insulin resistance. Am J Pathol. 2013;182(6):2254-2263. doi: https://doi.org/10.1016/j.ajpath.2013.02.019Cejvanovic V, Kjær LK, Bergholdt HKM, et al. Iron induced rna-oxidation in the general population and in mouse tissue. Free Radic Biol Med. 2018;115:127-135. doi: https://doi.org/10.1016/j.freeradbiomed.2017.11.013Cejvanovic V, Kjær LK, Bergholdt HKM, et al. Iron induced rna-oxidation in the general population and in mouse tissue. Free Radic Biol Med. 2018;115:127-135. doi: https://doi.org/10.1016/j.freeradbiomed.2017.11.013Tiongco RE, Arceo E, Clemente B, Pineda-Cortel MR. Association of maternal iron deficiency anemia with the risk of gestational diabetes mellitus: a meta-analysis. Arch Gynecol Obstet. 2019;299(1):89-95. doi: https://doi.org/10.1007/s00404-018-4932-0Tiongco RE, Arceo E, Clemente B, Pineda-Cortel MR. Association of maternal iron deficiency anemia with the risk of gestational diabetes mellitus: a meta-analysis. Arch Gynecol Obstet. 2019;299(1):89-95. doi: https://doi.org/10.1007/s00404-018-4932-0Hershenfeld S, Ye C, Hanley AJ, et al. Serum Ferritin and Glucose Homeostasis in Women with Recent Gestational Diabetes. Can J Diabetes. 2019;43:567-572. doi: https://doi.org/10.1016/j.jcjd.2019.06.003Hershenfeld S, Ye C, Hanley AJ, et al. Serum Ferritin and Glucose Homeostasis in Women with Recent Gestational Diabetes. Can J Diabetes. 2019;43:567-572. doi: https://doi.org/10.1016/j.jcjd.2019.06.003WHO recommendations on antenatal care for a positive pregnancy experience. World Health Organization. (2016). Available from: www.who.int/reproductivehealth/publications/maternal_perinatal_health/anc-positive-pregnancy-experience/en/WHO recommendations on antenatal care for a positive pregnancy experience. World Health Organization. (2016). Available from: www.who.int/reproductivehealth/publications/maternal_perinatal_health/anc-positive-pregnancy-experience/en/Zhu B, Liang C, Xia X, et al. Iron-Related Factors in Early Pregnancy and Subsequent Risk of Gestational Diabetes Mellitus: the Ma’anshan Birth Cohort (MABC) Study. Biol Trace Elem Res. 2019;191(1):45-53. doi: https://doi.org/10.1007/s12011-018-1595-4Zhu B, Liang C, Xia X, et al. Iron-Related Factors in Early Pregnancy and Subsequent Risk of Gestational Diabetes Mellitus: the Ma’anshan Birth Cohort (MABC) Study. Biol Trace Elem Res. 2019;191(1):45-53. doi: https://doi.org/10.1007/s12011-018-1595-4Liu X, Pang J. A retrospective study of supplemental iron intake in singleton pregnancy women with risk of developing gestational diabetes mellitus. Medicine. 2018;97(26):e10819. doi: https://doi.org/10.1097/MD.0000000000010819Liu X, Pang J. A retrospective study of supplemental iron intake in singleton pregnancy women with risk of developing gestational diabetes mellitus. Medicine. 2018;97(26):e10819. doi: https://doi.org/10.1097/MD.0000000000010819

The authors declare that there are no conflicts of interest present.