diaendoСахарный диабетDiabetes mellitus2072-03512072-0378Endocrinology research centre10.14341/DM12485diaendo-12485Research ArticleОбзорыReviewГипергликемия и возможные механизмы повреждения β-клеток у пациентов с COVID-19Hyperglycemia and possible mechanisms of β-cell damage in patients with COVID-19https://orcid.org/0000-0002-2612-5253КалмыковаЗиля АсхатовнаKalmykovaZ. A.

аспирант

MD, PhD student

zilya.kalmykova@gmail.comhttps://orcid.org/0000-0003-4929-1526КононенкоИрина ВладимировнаKononenkoI. V.

к.м.н., в.н.с.

MD, PhD, leading research associate

shakhtarina@bk.ruhttps://orcid.org/0000-0002-7768-4717СкляникИгорь АлександровичSklyanikI. A.

н.с.

MD, research associate

sklyanik.igor@gmail.comhttps://orcid.org/0000-0002-5057-127XШестаковаМарина ВладимировнаShestakovaM. V.

д.м.н., профессор, академик РАН

MD, PhD, Professor

nephro@endocrincentr.ruhttps://orcid.org/0000-0002-9717-9742МокрышеваНаталья ГеоргиевнаMokryshevaN. G.

д.м.н., профессор, член-корр. РАН

MD, PhD, Professor

nm70@mail.ruНациональный медицинский исследовательский центр эндокринологииРоссияEndocrinology Research CentreRussian Federation202010082020233229234Copyright © Калмыкова З.А., Кононенко И.В., Скляник И.А., Шестакова М.В., Мокрышева Н.Г., 20202020Калмыкова З.А., Кононенко И.В., Скляник И.А., Шестакова М.В., Мокрышева Н.Г.Kalmykova Z.A., Kononenko I.V., Sklyanik I.A., Shestakova M.V., Mokrysheva N.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.dia-endojournals.ru/jour/article/view/12485

Актуальнейшим вопросом как отечественного, так и мирового здравоохранения является пандемия новой коронавирусной инфекции COVID-19, вызванной вирусом SARS-CoV-2. Уже установлено, что наибольшая подверженность заболеванию и более тяжелое его течение отмечаются у лиц с различными хроническими заболеваниями, в частности с сахарным диабетом (СД). Однако стали появляться первые данные о развитии на фоне новой коронавирусной инфекции стрессовой, или транзиторной, гипергликемии. В данной статье приведен обзор сообщений зарубежных врачей-исследователей о зарегистрированных случаях гипергликемии на фоне COVID-19. Описаны возможные механизмы развития гипергликемии при COVID-19 с учетом особенностей патогенеза и течения заболевания, репродукции SARS-CoV-2 по данным отечественной и зарубежной литературы.

Progressive decrease in the weight and functional reserve of β-cells is one of the main pathogenetic mechanisms of development of type 2 diabetes mellitus (DM2). The rate of progression of these processes is strictly individual, which largely determines the course of DM2 and the effectiveness of the therapy. As a rule, apoptosis and necrosis are the main mechanisms of β-cell damage and death in CD2. At the same time, recent studies allow us to consider the destruction and death of β-cells as the outcome of other types of programmed cell death (PCG), the role of innate immunity in the Genesis of CD2 IS actively discussed. This article provides an overview of the data of domestic and foreign literature of recent years regarding the molecular, intracellular characteristics of different types of β-cell PCG in CD2. The results of studies aimed at studying the possible factors and processes leading to their launch are presented.

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The authors declare that there are no conflicts of interest present.