diaendoСахарный диабетDiabetes mellitus2072-03512072-0378Endocrinology research centre10.14341/DM12313diaendo-12313Research ArticleОбзорыReviewФактор транскрипции 7 (TCF7L2): фактор риска развития сахарного диабета 2 типаTranscription factor 7-like 2 (TCF7L2): a culprit gene in Type 2 Diabetes Mellitushttps://orcid.org/0000-0003-3880-5579JanA.JanA.

Пешавар

Asif Jan, Khyber Pakhtunkhwa (KP)

Peshawar

Asif.research1@gmail.comhttps://orcid.org/0000-0002-1792-2912JanH.JanH.

Пешавар

Humerah Jan

Peshawar

Humerahjan@gmail.comhttps://orcid.org/0000-0001-7932-9498UllahZ.UllahZ.

Пешавар

Zaki Ullah

Peshawar

zakiullah@uop.edu.pkКафедра фармации, университет ПешавараПакистанDepartment of Pharmacy, University of PeshawarPakistanКафедра химии, Исламия-колледжПакистанDepartment of Chemistry, Islamia College UniversityPakistan202115082021244371376Copyright © Jan A., Jan H., Ullah Z., 20212021Jan A., Jan H., Ullah Z.Jan A., Jan H., Ullah Z.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.dia-endojournals.ru/jour/article/view/12313

Влияние генетических факторов на развитие сахарного диабета 2 типа (СД2) крайне многогранно и до сих пор остается одним из главных вопросов диабетологии. В 2006 г. важным шагом в поиске генетических факторов развития СД2 стала идентификация гена TCF7L2, который является важным маркером предрасположенности к СД2 почти у всех этнических групп. Недавние генетические исследования выявили множество новых генов, ассоциированных с повышенным риском развития СД2. Среди этих генов TCF7L2 оказался наиболее многообещающим, связанным с СД2. Генотипы TCF7L2 оказывают влияние на развитие бета-клеток поджелудочной железы и секрецию инсулина, воздействуя на сигнальный путь Wnt. Определенные полиморфизмы гена TCF7L2 увеличивают риск развития СД2, изменяя экспрессию фактора транскрипции (который играет ключевую роль в регуляции уровня глюкозы в крови) в поджелудочной железе. Цель данной статьи — представить всесторонний обзор исследований по ассоциации полиморфизма TCF7L2 с СД2, проведенных в различных этнических группах во всем мире.

The genetics of Type 2 diabetes a complex metabolic disorder, characterized by decreased insulin secretion and insulin resistance resulting in impaired blood glucose homeostasis remains enigma for geneticists. In 2006 an important step while finding genetic causes of diabetes type 2 was identification of transcription factor 7-like 2 (TCF7L2) gene an important marker in predisposition of type 2 diabetes in almost all ethnic population. Recent genetic research identifies numerous novel type 2 diabetes susceptible genes among these genes TCF7L2 is considered as gang head and emerged as the most promising types 2 diabetes causing gene. Risk variants in TCF7L2 effects pancreatic beta cell development and insulin secretion by influencing Wnt Signaling pathway. Genetic variants in TCF7L2 confer risk for type 2 diabetes by altering expression of transcription factor (which has key role in blood glucose regulation) in pancreas. The purpose of this paper is to evaluate type 2 diabetes susceptible gene the TCF7L2 and to present a comprehensive review of studies carried out worldwide in different ethnic population on association of TCF7L2 polymorphism with type 2 diabetes.

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The authors declare that there are no conflicts of interest present.