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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">diaendo</journal-id><journal-title-group><journal-title xml:lang="ru">Сахарный диабет</journal-title><trans-title-group xml:lang="en"><trans-title>Diabetes mellitus</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-0351</issn><issn pub-type="epub">2072-0378</issn><publisher><publisher-name>Endocrinology research centre</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14341/DM12260</article-id><article-id custom-type="elpub" pub-id-type="custom">diaendo-12260</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Оригинальные исследования</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Original Studies</subject></subj-group></article-categories><title-group><article-title>Профиль заболевания периферических артерий при сахарном диабете 2 типа - стационарное обсервационное обследование, проведенное в Прибрежной Карнатаке</article-title><trans-title-group xml:lang="en"><trans-title>Profile of Peripheral Arterial Disease in Type 2 Diabetes Mellitus - A Hospital-based observational study in Coastal Karnataka</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Arora</surname><given-names>Esha</given-names></name><name name-style="western" xml:lang="en"><surname>Arora</surname><given-names>Esha</given-names></name></name-alternatives><bio xml:lang="ru"><p>Манипал, Карнатака</p></bio><bio xml:lang="en"><p>Manipal, Karnataka</p></bio><email xlink:type="simple">eshampt@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Korada</surname><given-names>Hrishikesh</given-names></name><name name-style="western" xml:lang="en"><surname>Korada</surname><given-names>Hrishikesh</given-names></name></name-alternatives><bio xml:lang="ru"><p>Манипал, Карнатака</p></bio><bio xml:lang="en"><p>Manipal, Karnataka</p></bio><email xlink:type="simple">hrishi.yadav99@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Devasia</surname><given-names>Tom</given-names></name><name name-style="western" xml:lang="en"><surname>Devasia</surname><given-names>Tom</given-names></name></name-alternatives><bio xml:lang="ru"><p>Манипал, Карнатака</p></bio><bio xml:lang="en"><p>Manipal, Karnataka</p></bio><email xlink:type="simple">arun.maiya.g@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Bhat</surname><given-names>Rama</given-names></name><name name-style="western" xml:lang="en"><surname>Bhat</surname><given-names>Rama</given-names></name></name-alternatives><bio xml:lang="ru"><p>Манипал, Карнатака</p></bio><bio xml:lang="en"><p>Manipal, Karnataka</p></bio><email xlink:type="simple">tomdevasia@hotmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Kamath</surname><given-names>Ganesh</given-names></name><name name-style="western" xml:lang="en"><surname>Kamath</surname><given-names>Ganesh</given-names></name></name-alternatives><bio xml:lang="ru"><p>Манипал, Карнатака</p></bio><bio xml:lang="en"><p>Manipal, Karnataka</p></bio><email xlink:type="simple">ram.bhat@manipal.edu</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Maiya</surname><given-names>Arun</given-names></name><name name-style="western" xml:lang="en"><surname>Maiya</surname><given-names>Arun</given-names></name></name-alternatives><bio xml:lang="ru"><p>Манипал, Карнатака</p></bio><bio xml:lang="en"><p>Dean, Professor.</p></bio><email xlink:type="simple">arun.maiya.g@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Manipal College of Health Professions, Manipal Academy of Higher Education</institution><country>Индия</country></aff><aff xml:lang="en"><institution>Manipal College of Health Professions, Manipal Academy of Higher Education</institution><country>India</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Kasturba Medical College, Manipal Academy of Higher Education</institution><country>Индия</country></aff><aff xml:lang="en"><institution>Kasturba Medical College, Manipal Academy of Higher Education</institution><country>India</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>01</day><month>12</month><year>2020</year></pub-date><volume>23</volume><issue>4</issue><fpage>324</fpage><lpage>328</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Arora E., Korada H., Devasia T., Bhat R., Kamath G., Maiya A., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Arora E., Korada H., Devasia T., Bhat R., Kamath G., Maiya A.</copyright-holder><copyright-holder xml:lang="en">Arora E., Korada H., Devasia T., Bhat R., Kamath G., Maiya A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.dia-endojournals.ru/jour/article/view/12260">https://www.dia-endojournals.ru/jour/article/view/12260</self-uri><abstract><sec><title>Обоснование</title><p>Обоснование. Лодыжечно-плечевой индекс (ЛПИ) - достаточно распространенный неинвазивный метод, применяемый для диагностики заболеваний периферических артерий (ЗПА). Однако было отмечено, что у пациентов с диагнозом ЗПА и сахарным диабетом 2 типа (СД2) ЛПИ не имеет диагностической ценности в связи с кальцификацией крупных артерий нижних конечностей. Таким образом, врачи могут быть введены в заблуждение относительно диагностики ЗПА. Для этого был разработан другой метод диагностики - пальце-плечевой индекс (ППИ). Однако объем литературы, содержащей сведения о применении ЛПИ и ППИ в одной группе в рамках одного исследования, ограничен.</p></sec><sec><title>Цель</title><p>Цель. Целью данного исследования является описание профилей ЛПИ и ППИ наряду с такими классическими симптомами, как боль при хромоте, пальпация пульса и анамнез СД2 для проведения скрининга и диагностирования ЗПА при СД2.</p></sec><sec><title>Методы</title><p>Методы. Для участия в данном поперечном обсервационном обследовании в соответствии с критериями включения была набрана группа в количестве 121 участника с установленным диагнозом СД2. Были собраны детальные демографические данные участников. Всем участникам был проведена диагностика с помощью диагностических методов ЛПИ и ППИ, а полученные данные были проанализированы.</p></sec><sec><title>Результаты</title><p>Результаты. Из 121 участника только 3 участника имели положительный результат по обоим методам ЛПИ и ППИ, что означает положительный результат диагностики ЗПА, у 106 участников оба метода ЛПИ и ППИпоказали отрицательный результат. Однако среди оставшихся 12 участников были выявлены следующие результаты: у 10 участников ППИ положительный, а ЛПИ отрицательный, у 2 участников ЛПИ положительный, а ППИ отрицательный.</p></sec><sec><title>Заключение</title><p>Заключение. В результате проведенного исследования мы установили ЗПА при СД2 в 10,75% случаев. Таким образом, считаем, что для выявления осложнений должны быть использованы оба метода - ЛПИ и ППИ. Это сыграет определенную положительную роль при ранней диагностике и установлении нейроишемических изменений в стопе и, соответственно, позволит избежать ампутации.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction: Ankle Brachial Index (ABI) is one of the common non-invasive diagnostic tools available for diagnosing Peripheral Arterial Disease (PAD). However, it has been observed that for an individual diagnosed with both PAD and Type 2 Diabetes Mellitus (T2DM), ABI tends to give false diagnostic value because of the calcification of the major lower limb arteries. Therefore, the health care professionals are at times misled for the diagnosis of PAD. To overcome this another diagnostic tool Toe Brachial Index (TBI) was suggested to perform. However, there is limited literature on performing both ABI and TBI in the given population in a single study.</p></sec><sec><title>Aim</title><p>Aim: The main focus of this study is to report the profile of ABI and TBI along with classical symptoms like claudication pain, palpation of pulse and history of T2DM for the screening and diagnosis of PAD in T2DM.</p></sec><sec><title>Materials And Methods</title><p>Materials And Methods: In this cross-sectional observational study, a total of 121 participants diagnosed with T2DM were recruited for the study as per the inclusion criteria. Detailed demographic details of the participants were noted. Diagnostic tool including both ABI and TBI were performed for all the participants and the data was analysed.</p></sec><sec><title>Results</title><p>Results: Among 121 participants, only 3 participants had both ABI and TBI positive indicating positive diagnostic test for PAD and 106 participants had both ABI and TBI negative. However, in the remaining 12 participants, 10 showed TBI positive but ABI negative and 2 had ABI positive but TBI negative.</p></sec><sec><title>Conclusions</title><p>Conclusions: Based on our study we have reported the profile of PAD in T2DM individuals, which is found to be 10.75.%. Therefore, it can be concluded that ABI and TBI both should be performed to rule out any complication. This will be beneficial in early screening and detection of neuro ischemic changes in foot and subsequently to prevent amputation.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>заболевание периферических артерий</kwd><kwd>сахарный диабет 2 типа</kwd><kwd>пальце-плечевой индекс</kwd><kwd>обсервационное обследование</kwd></kwd-group><kwd-group xml:lang="en"><kwd>peripheral arterial disease</kwd><kwd>type 2 diabetes mellitus</kwd><kwd>toe brachial index</kwd><kwd>observational study</kwd></kwd-group><funding-group><funding-statement xml:lang="en">We thank Kody Medical Electronics Pvt Ltd., Chennai, India for their interest and for providing the Hadeco Smartdop 30 EX doppler. We thank the World Diabetes Foundation WDF 15-941 and Centre for Diabetic Foot Care and Research for supporting the study and Manipal Academy of Higher Education for their Approval</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Litwak L, Goh SY, Hussein Z, et al. Prevalence of diabetes complications in people with type 2 diabetes mellitus and its association with baseline characteristics in the multinational A 1 chieve study. Diabetol Metab Syndr. 2013;5(1)57. doi: https://doi.org/10.1186/1758-5996-5-57.</mixed-citation><mixed-citation xml:lang="en">Litwak L, Goh SY, Hussein Z, et al. Prevalence of diabetes complications in people with type 2 diabetes mellitus and its association with baseline characteristics in the multinational A 1 chieve study. Diabetol Metab Syndr. 2013;5(1)57. doi: https://doi.org/10.1186/1758-5996-5-57.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Hernando S, Francisco J, Conejero AM. [Peripheral artery disease: pathophysiology, diagnosis and treatment. (In Spanish)]. RevEsp Cardiol. 2007;60(9):969-982. doi: https://doi.org/10.1157/13109651.</mixed-citation><mixed-citation xml:lang="en">Hernando S, Francisco J, Conejero AM. [Peripheral artery disease: pathophysiology, diagnosis and treatment. (In Spanish)]. RevEsp Cardiol. 2007;60(9):969-982. doi: https://doi.org/10.1157/13109651.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Agarwal AK, Singh M, Arya V, et al. Prevalence of peripheral arterial disease in type 2 diabetes mellitus and its correlation with coronary artery disease and its risk factors. J Assoc Physicians India. 2012;60(7):28-32.</mixed-citation><mixed-citation xml:lang="en">Agarwal AK, Singh M, Arya V, et al. Prevalence of peripheral arterial disease in type 2 diabetes mellitus and its correlation with coronary artery disease and its risk factors. J Assoc Physicians India. 2012;60(7):28-32.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Arora E, Maiya AG, Devasia T, et al. Prevalence of peripheral arterial disease among type 2 diabetes mellitus in coastal Karnataka. Diabetes Metab Syndr. 2019;13(2):1251-1253. doi: https://doi.org/10.10167j.dsx.2019.02.003.</mixed-citation><mixed-citation xml:lang="en">Arora E, Maiya AG, Devasia T, et al. Prevalence of peripheral arterial disease among type 2 diabetes mellitus in coastal Karnataka. Diabetes Metab Syndr. 2019;13(2):1251-1253. doi: https://doi.org/10.10167j.dsx.2019.02.003.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Jude EB, Eleftheriadou I, Tentolouris N. Peripheral arterial disease in diabetes - a review. Diabet Med. 2010;27(1):4-14. doi: https://doi.org/10.1111Zj.1464-54912009.02866x</mixed-citation><mixed-citation xml:lang="en">Jude EB, Eleftheriadou I, Tentolouris N. Peripheral arterial disease in diabetes - a review. Diabet Med. 2010;27(1):4-14. doi: https://doi.org/10.1111Zj.1464-54912009.02866x</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Andras A, Ferket B. Screening for peripheral arterial disease. Cochrane Database Syst Rev. 2014;(4):CD010835. doi: https://doi.org/10.1002/14651858.CD010835.pub2.</mixed-citation><mixed-citation xml:lang="en">Andras A, Ferket B. Screening for peripheral arterial disease. Cochrane Database Syst Rev. 2014;(4):CD010835. doi: https://doi.org/10.1002/14651858.CD010835.pub2.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Romanos MT, Raspovic A, Perrin BM. The reliability of toe systolic pressure and the toe brachial index in patients with diabetes. J Foot Ankle Res. 2010;3(1):31. doi: https://doi.org/10.1186/1757-1146-3-31.</mixed-citation><mixed-citation xml:lang="en">Romanos MT, Raspovic A, Perrin BM. The reliability of toe systolic pressure and the toe brachial index in patients with diabetes. J Foot Ankle Res. 2010;3(1):31. doi: https://doi.org/10.1186/1757-1146-3-31.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Collins R, Burch J, Cranny G, et al. Duplex ultrasonography, magnetic resonance angiography, and computed tomography angiography for diagnosis and assessment of symptomatic, lower limb peripheral arterial disease: a systematic review. BMJ. 2007;334(7606):1257. doi: https://doi.org/10.1136/bmj.39217.473275.55.</mixed-citation><mixed-citation xml:lang="en">Collins R, Burch J, Cranny G, et al. Duplex ultrasonography, magnetic resonance angiography, and computed tomography angiography for diagnosis and assessment of symptomatic, lower limb peripheral arterial disease: a systematic review. BMJ. 2007;334(7606):1257. doi: https://doi.org/10.1136/bmj.39217.473275.55.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Tehan PE, Santos D, Chuter VH. A systematic review of the sensitivity and specificity of the toe-brachial index for detecting peripheral artery disease. Vasc Med. 2016;21(4):382-389. doi: https://doi.org/10.1177/1358863X16645854.</mixed-citation><mixed-citation xml:lang="en">Tehan PE, Santos D, Chuter VH. A systematic review of the sensitivity and specificity of the toe-brachial index for detecting peripheral artery disease. Vasc Med. 2016;21(4):382-389. doi: https://doi.org/10.1177/1358863X16645854.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Park SC, Choi CY, Ha YI, Yang HE. Utility of toe-brachial index for diagnosis of peripheral artery disease. Arch Plast Surg. 2012;39(3):227-231. doi: https://doi.org/10.5999/aps.2012.393.227.</mixed-citation><mixed-citation xml:lang="en">Park SC, Choi CY, Ha YI, Yang HE. Utility of toe-brachial index for diagnosis of peripheral artery disease. Arch Plast Surg. 2012;39(3):227-231. doi: https://doi.org/10.5999/aps.2012.393.227.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Cade WT. Diabetes-related microvascular and macrovascular diseases in the physical therapy setting. Phys Ther. 2008;88(1 1):1322-1335. doi: https://doi.org/10.2522/ptj.20080008.</mixed-citation><mixed-citation xml:lang="en">Cade WT. Diabetes-related microvascular and macrovascular diseases in the physical therapy setting. Phys Ther. 2008;88(1 1):1322-1335. doi: https://doi.org/10.2522/ptj.20080008.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Eshcol J, Jebarani S, Anjana RM, et al. Prevalence, incidence and progression of peripheral arterial disease in Asian Indian type 2 diabetic patients. J Diabetes Complications. 2014;28(5):627-631. doi: https://doi.org/10.1016/jJdiacomp.2014.04.013.</mixed-citation><mixed-citation xml:lang="en">Eshcol J, Jebarani S, Anjana RM, et al. Prevalence, incidence and progression of peripheral arterial disease in Asian Indian type 2 diabetic patients. J Diabetes Complications. 2014;28(5):627-631. doi: https://doi.org/10.1016/jJdiacomp.2014.04.013.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Bowling FL, Rashid ST, Boulton AJ. Preventing and treating foot complications associated with diabetes mellitus. Nat Rev Endocrinol. 2015;11(10):606-616. doi: https://doi.org/10.1038/nrendo.2015.130.</mixed-citation><mixed-citation xml:lang="en">Bowling FL, Rashid ST, Boulton AJ. Preventing and treating foot complications associated with diabetes mellitus. Nat Rev Endocrinol. 2015;11(10):606-616. doi: https://doi.org/10.1038/nrendo.2015.130.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Brooks B, Dean R, Patel S, et al. TBI or not TBI: that is the question. Is it better to measure toe pressure than ankle pressure in diabetic patients? Diabet Med. 2001;18(7):528-532. doi: https://doi.org/10.1046/j.1464-5491.2001.00493.x.</mixed-citation><mixed-citation xml:lang="en">Brooks B, Dean R, Patel S, et al. TBI or not TBI: that is the question. Is it better to measure toe pressure than ankle pressure in diabetic patients? Diabet Med. 2001;18(7):528-532. doi: https://doi.org/10.1046/j.1464-5491.2001.00493.x.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">American Diabetes Association. Microvascular complications and foot care. Diabetes care. 2015;38(Suppl 1):S58-66. doi: https://doi.org/10.2337/dc15-S012.</mixed-citation><mixed-citation xml:lang="en">American Diabetes Association. Microvascular complications and foot care. Diabetes care. 2015;38(Suppl 1):S58-66. doi: https://doi.org/10.2337/dc15-S012.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Armstrong DG, Fisher TK, Lepow B, et al. 26. Pathophysiology and principles of management of the diabetic foot. In: Fitridge R, Thompson M. Mechanisms of vascular disease: a reference book for vascular specialists [Internet]. Adelaide (AU): University of Adelaide Press; 2011.</mixed-citation><mixed-citation xml:lang="en">Armstrong DG, Fisher TK, Lepow B, et al. 26. Pathophysiology and principles of management of the diabetic foot. In: Fitridge R, Thompson M. Mechanisms of vascular disease: a reference book for vascular specialists [Internet]. Adelaide (AU): University of Adelaide Press; 2011.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
