diaendoСахарный диабетDiabetes mellitus2072-03512072-0378Endocrinology research centre10.14341/DM10302diaendo-10302Research ArticleОригинальные исследованияOriginal StudiesКонцентрация электролитов сыворотки крови у пациентов с сахарным диабетом 2 типа: поперечное исследованиеSerum electrolytes levels in patients with type 2 diabetes mellitus: a cross-sectional studyhttps://orcid.org/0000-0002-2168-075XReshmaShridhar

MD

drreshmakiran@gmail.comhttps://orcid.org/0000-0001-8047-9127SushithSushith

MD

drsushith@yahoo.comhttps://orcid.org/0000-0002-2302-254XPrathimaMangalore Balakrishna

MD; ORCID

mbprathima@gmail.comhttps://orcid.org/0000-0003-3002-1649JaniceD'Sa

MD

janicedsa@gmail.comhttps://orcid.org/0000-0002-2678-0303MadanGopal R

MD

madanbiochem@gmail.comhttps://orcid.org/0000-0002-6964-968XGowdaPragathi

MD

gowdap@gmail.comhttps://orcid.org/0000-0003-0144-7341KumarKiran PK

MD

kumarpk@gmail.comhttps://orcid.org/0000-0002-4654-4332RaiMohandas

MD

mohandassrao@gmail.comhttps://orcid.org/0000-0002-2560-3778KalalBhuvanesh Sukhlal

PhD

bhuvanesh611@gmail.comA.J. Institute of Medical Sciences and Research CentreIndia202010082020233223228Copyright © Reshma S., Sushith S., Prathima M.B., Janice D., Madan G.R., Gowda P., Kumar K.P., Rai M., Kalal B.S., 20202020Reshma S., Sushith S., Prathima M.B., Janice D., Madan G.R., Gowda P., Kumar K.P., Rai M., Kalal B.S.Reshma S., Sushith S., Prathima M.B., Janice D., Madan G.R., Gowda P., Kumar K.P., Rai M., Kalal B.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.dia-endojournals.ru/jour/article/view/10302АКТУАЛЬНОСТЬ

АКТУАЛЬНОСТЬ. Сахарный диабет (СД) – это частое метаболическое заболевание, распространенное во всем мире. Электролиты играют большую роль в нормальном функционировании организма, нарушение регуляции служит признаком различных типов заболевания. Электролитные нарушения часто выявляют при СД 2 типа (СД2).

ЦЕЛЬ

ЦЕЛЬ. Целью этого исследования было определение концентрации электролитов сыворотки крови у амбулаторных пациентов с СД2 и выявление корреляции между их уровнями и концентрацией глюкозы в крови при случайном измерении (случайный уровень глюкозы – СУГ).

МЕТОДЫ

МЕТОДЫ. В исследование включены пациенты с СД2, посещающие амбулаторное отделение Биохимии и медицины в период с апреля 2016 г. по март 2017 г. Из 148 пациентов с диагностированным СД2 у 74 пациентов СУГ был >300 мг/дл (группа 1) и у 74 пациентов – ≤300 мг/дл (группа 2). Концентрации натрия (Na+), калия (K+), хлорида (Cl-) измеряли с помощью анализатора электролитов Roche 9180.

РЕЗУЛЬТАТЫ

РЕЗУЛЬТАТЫ. В этом исследовании в группе 1 выявлено значимое снижение концентрации Na+ в сыворотке крови (131,83±4,36 ммоль/л) по сравнению с группой 2 (134,15±4,90 ммоль/л). Концентрация K+ в сыворотке крови была выше в группе 1 (4,51±0,61 ммоль/л) по сравнению с группой 2 (4,26±0,52 ммоль/л). В группе 1 отмечена статистически значимая обратная корреляция между Na+ (r=-0,342) и Cl- (r=-0,538) сыворотки крови и СУГ. В группе 2 значимая корреляция обнаружена между концентрацией K+ в сыворотке крови и СУГ (r=0,356, p<0,05).

ЗАКЛЮЧЕНИЕ

ЗАКЛЮЧЕНИЕ. Исследование показало, что в группе 1 концентрации Na+ были ниже, а K+ выше, чем в группе 2. Результаты исследования показали, что у пациентов с СД распределение концентраций Na+ и K+ в сыворотке крови зависит от концентрации глюкозы в плазме крови, и также свидетельствуют об обоснованности контроля концентраций электролитов при гипергликемии в лечении СД.

BACKGROUND

BACKGROUND: Diabetes Mellitus (DM) is a common metabolic disease worldwide. Electrolyte played significant roles in the normal functioning of the body, and deregulation is indicative of different types of disease and electrolyte disturbances are often reported in type 2 DM (T2DM).

AIM

AIM: The aim of the study was to estimate the levels of serum electrolytes in outpatients with T2DM and correlate serum electrolytes with random blood sugar (RBS).

MATERIALS AND METHODS

MATERIALS AND METHODS: Patients with T2DM visiting the outpatient Departments of Medicine, between April 2016 and March 2017 were included. Of 148 diagnosed T2DM cases, 74 were had RBS level >300mg/dL (group-1) and 74 had RBS level ≤300mg/dL (group-2). Serum sodium (Na+), potassium (K+), chloride (Cl-) levels were measured by using the Roche 9180 electrolyte analyzer.

RESULTS

RESULTS: In this study, there was a significant decrease in serum Na+ levels in group 1 (131.83±4.36 mmol/L) compared to group 2 (134.15±4.90 mmol/L).The serum levels of K+ was found to be increased in group 1 (4.51±0.61 mmol/L) in comparison with group 2 (4.26±0.52 mmol/L). In group-1, an inverse relationship was present between serum Na+ (r=-0.342) and Cl- (r=-0.538) with RBS which was statistically significant. In group-2, a significant correlation was present between serum K+ and RBS (r=0.356, p<0.05).

CONCLUSIONS

CONCLUSIONS: The study showed lower levels of Na+ and higher K+ levels in group-1 compared to group-2 subjects. This study showed that the distribution of serum Na+ and K+ levels is dependent on plasma glucose levels in patients with DM and also suggests that monitoring the electrolyte levels in hyperglycemia is pertinent in the management of diabetes.

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The authors declare that there are no conflicts of interest present.